The RLG-I like receptor signaling pathway plays an important role in preventing the body from being infected by viruses. For this immune defense, the virus has some strategies to interfere with this process. After a virus infects cells, it often destroys the transduction of the RLR signaling ...
which can bind the pathogenic correlation molecular formula and RNA ligand to identify non-own viral RNA,activate the RIG-I signaling pathway,promote the production of cytokines and exert the antiviral effect.This study reviews the various signaling pathways and regulatory mechanisms of RIG-I like ...
RIG-I-like receptor signaling pathway Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helica...
Accumulating evidence suggests that the presence of intact type I IFN signaling is critical for the efficacy of many conventional chemotherapeutics and targeted anticancer agents [109]. Given that RLRs are critical for activating the IFN responses and inducing immunogenic cell death, stimulation of RIG-...
Interferons are important components of the host innate immune response. Type I IFNs (IFN-α, -β, -ε and -Ω) engage IFN-α/β receptor (IFNAR) and activate the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway, leading to the expression of interferon-...