The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory...
RIG-I like Receptor Signaling PathwayOverview Diagram Introduction A variety of pathogens, including viruses, can trigger an innate cellular immune response that is essential to limit the early spread of pathogens. After the virus infects the body, the development of effective antiviral natural ...
RNA,activate the RIG-I signaling pathway,promote the production of cytokines and exert the antiviral effect.This study reviews the various signaling pathways and regulatory mechanisms of RIG-I like receptors,providing new ideas and directions for the control of viral infection and immunomodulatory ...
本文简单介绍了RL R信号通路的组成及其泛素化调控 ,总结了病毒逃避RL R 通路信号转 导的机制,最后阐述了NOD样受体 ( NOD. 1ike receptors,NLR s) 通路对RL R通路的影响。通过对RL R信号通路分子在抗病毒 免疫调节中的作用了解,可以为控制病毒的感染和免疫调节提供一个新的思路。 关键词:R I G. I样受体;...
Toll-Like Receptor Pathway and Its Targeting in Treatment of Cancers Chapter An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation Introduction Chronic infection and inflammation are established risk factors for car...
The target genes of the differently expressed miRNAs in the two libraries were predicted, and some candidate target genes were involved in the RIG-I-like receptor (RLR) signaling pathway. The negative regulation of miRNAs to target genes were confirmed by comparing the expression pattern of miRNAs...
(2023) 16:8 Journal of Hematology & Oncology REVIEW Open Access Exploiting RIG‑I‑like receptor pathway for cancer immunotherapy Yangfu Jiang1*, Hongying Zhang1, Jiao Wang2, Jinzhu Chen1, Zeyu Guo1, Yongliang Liu1 and Hui Hua3* Abstract RIG-I-like ...
HSCARG Negatively Regulates the Cellular Antiviral RIG-I Like Receptor Signaling Pathway by Inhibiting TRAF3 Ubiquitination via Recruiting OTUB1. RIG-I like receptors (RLRs) recognize cytosolic viral RNA and initiate innate immunity; they increase the production of type I interferon (IFN) and the tr...
Interferons are important components of the host innate immune response. Type I IFNs (IFN-α, -β, -ε and -Ω) engage IFN-α/β receptor (IFNAR) and activate the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway, leading to the expression of interferon-...
In our previous articles, we focused on the role of toll-like receptor 3 (TLR3) in this signaling pathway. Here, we define the role of another innate immunity pathway known to participate in response to viral RNA, the retinoic acid-inducible gene 1 receptor (RIG-1)-like receptor (RLR) ...