RIG-I-like receptor signaling pathway Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helica...
The RLG-I like receptor signaling pathway plays an important role in preventing the body from being infected by viruses. For this immune defense, the virus has some strategies to interfere with this process. After a virus infects cells, it often destroys the transduction of the RLR signaling ...
which can bind the pathogenic correlation molecular formula and RNA ligand to identify non-own viral RNA,activate the RIG-I signaling pathway,promote the production of cytokines and exert the antiviral effect.This study reviews the various signaling pathways and regulatory mechanisms of RIG-I like ...
thereby suppressing RIG-I activation and antiviral responses [102]. In addition, the EBV large tegument protein BPLF1 sequesters TRIM25 and prevents the ubiquitination of RIG-I by TRIM25, leading to impaired RIG-I signaling [103]. Meanwhile, EBV-encoded LMP1 can promote proteasomal degradation of...
which may disable the DNA sensing pathway [262,263]. Therefore, the levels of TREX1 or other negative regulators of DNA sensing may determine the extent to which STING signaling is activated after radiotherapy. On the other hand, the leaked mtRNA can engage RLR-MAVS signaling pathway to induc...