Melanoma differentiation-associated protein 5 (MDA5) and retinoic acid-inducible gene 1 (RIG-1) as the pattern recognition receptors play important roles in viral mRNA recognition. Chronic HBV-infected (CHB) patients are unable to properly respond to hepatitis B virus (HBV). Therefore, the aim ...
MA5-31715 has been tested in indirect ELISA. 靶标信息 Retinoic acid-inducible gene I, RIG-I is a pattern recognition receptor (PRR) involved in the recognition of viral dsRNA. Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response. Both MDA5 and RIG-I are ...
RIG-1 recognizes relatively short dsRNA (up to 1 kb) whereas MDA5 detects long dsRNA (more than 2 kb) to activate synthesis of type I IFNs, including IFN-α and IFN-β [7]. RLRs are localized in the cytoplasm and recognize the genomic RNA of dsRNA viruses and dsRNA generated as the...
RIG-1 recognizes relatively short dsRNA (up to 1 kb) whereas MDA5 detects long dsRNA (more than 2 kb) to activate synthesis of type I IFNs, including IFN-α and IFN-β [7]. RLRs are localized in the cytoplasm and recognize the genomic RNA of dsRNA viruses and dsRNA generated as the...
However, the regulation of MDA5 signal-transducing ability remains unclear. Here, we show that MDA5 signaling activity is regulated by a dynamic balance between phosphorylation and dephosphorylation of its caspase recruitment domains (CARDs). Employing a phosphatome RNAi screen, we identified PP1α ...
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol. 6(10):981-988. Figures Validation of RIG-I knockout Functional validation of RIG-I knockout (IRF response) Functional validation of RIG-I knockout (NF-κB response) Back to the top ...
背景资料 RIG-I (retinoic acid-inducible gene I) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded (in humans) by the DDX58 gene.RIG-I is part of the RIG-I-like receptor family,which also includes MDA5 and LGP2,and functions as a pattern recognition receptor that is a ...
Comparative intermolecular interaction of RIG1 and MDA5 (human and buffalo) with dsRNA.Manvender, SinghBiswajit, BrahmaJitendra, MaharanaMahesh, Chandra PatraSushil, KumarPurusottam, MishraMegha, SainiBidhan, Chandra DeSourav, MahantyTirtha, Kumar Datta...
ERAL1 MAVS TRIM25 RIG-1/MDA5 Introduction The capacity to distinguish self from non-self is the basic function of the immune system. Innate immunity is the first line of defense against invading pathogens. Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMP...
37 你看看是不是你要的，我不确定，如果不是就抱歉了 RIG-1.jpg 虽然不是，不过thank you too ...