RIG-I- and MDA5-Initiated Innate Immunity Linked With Adaptive Immunity Accelerates {beta}-Cell Death in Fulminant Type 1 Diabetes RIG-I- and MDA5-initiated innate immunity linked with adaptive immunity accelerates beta-cell death in fulminant type 1 diabetes. Diabetes. 2011;60(3):... K Aida...
斑马鱼模式识别受体NOD2、MDA5、RIG.I基因的免疫功能研究 达NOD2则不具有抑制E tarda增殖的效果。进一步研究发现,NOD2与RIPK2、 MAVS(mitochondria anti.virus signaling protein)、MDA5和ⅪG.I在诱导NF.r.B 和I型IFN启动子激活过程中存在相互作用,且NOD2可与MDA5和RIG.I蛋 白结合。上述结果表明,斑马鱼NOD2、...
RIG-I and MDA5 are the major intracellular immune receptors that recognize viral RNA species and undergo a series of conformational transitions leading to the activation of the interferon-mediated antiviral response. However, to date, full-length RLRs have resisted crystallographic efforts and a molecu...
产品活性:Polyinosinic-polycytidylic acid (Poly(I:C)) 是双链 RNA 的合成类似物,是一种 TLR3 和视黄酸诱导型基因 I 受体 (RIG-I 和 MDA5) 的激动剂。Polyinosinic-polycytidylic acid 可以用作疫苗佐剂,以增强先天性和适应性免疫反应,并改变肿瘤的微环境,还可以直接触发癌细胞发生凋亡 (apoptosis)。 体外:P...
Interestingly, type I and III IFNs coordinately induced IRF-1, RIG-I and MDA5; whereas type II IFN predominantly induced IRF-1 to exhibit their anti-norovirus activities. Combination of different IFNs revealed that IFNγ worked cooperatively with type I or type III IFNs to induce ISGs and ...
Here, we not only show that MDA5-mediated signaling is regulated by a dynamic balance between phosphorylation and dephosphorylation of its N-terminal CARDs but also identify the phosphatases PP1α and PP1γ as essential activators of both RIG-I and MDA5 signal transduction. Results The N-Termin...
Interestingly, type I and III IFNs coordinately induced IRF-1, RIG-I and MDA5; whereas type II IFN predominantly induced IRF-1 to exhibit their anti-norovirus activities. Combination of different IFNs revealed that IFNγ worked cooperatively with type I or type III IFNs to induce ISGs and ...
phosphorylation in uninfected cells ► MDA5 signaling activity is regulated by phosphorylation and dephosphorylation at S88 ► A functional screen identifies PP1α and PP1γ as activators of MDA5 and RIG-I ► PP1α and PP1γ are essential for RIG-I- and MDA5-mediated antiviral innate ...
37 你看看是不是你要的，我不确定，如果不是就抱歉了 RIG-1.jpg 虽然不是，不过thank you too ...
et al. A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection. Cell Res 31, 62–79 (2021). https://doi.org/10.1038/s41422-020-0362-1 Download citation Received24 February 2020 Accepted11 June 2020 Published01 ...