Mutation in ribosomal protein L21 underlies hereditary hypotrichosis simplex. C Zhou,D Zang,Y Jin,H Wu,Z Liu,J Du,J Zhang. Human Mutation . 2011C Zhou,D Zang,Y Jin,H Wu,Z Liu,J Du,J Zhang.Mutation in ribosomal protein L21 underlies hereditary hypotrichosis simplex. Human Mutation . ...
Suppression of a temperature-sensitive cdc33 mutation of yeast by a multicopy plasmid expressing a Drosophila ribosomal protein. J Biol Chem 1994; 269: 14625–14630. CAS PubMed Google Scholar Jimenez L, Becerra A, Landa A . Cloning, expression and partial characterization of a gene encoding ...
protein-protein interactions and increases in the translation rate of p53 mRNA. One of the best documented mechanisms of p53 induction upon nucleolar stress involves the binding of RPs to Mdm2 (mouse double minute 2; also referred to as HDM2 in human)...
Plants must coordinate ribosomes production to balance cellular protein synthesis in response to environmental variations and pathogens invasion. Over the past decade, research has revealed ribosome subgroups respond to adverse conditions, suggesting that this tight coordination may be grounded in the induct...
A point mutation in a gene encoding the putative transcription factor Xrp1 was isolated in a genetic screen designed to reveal defects in cell competition (Lee et al., 2016). The Xrp1 transcription unit on the right arm of the third chromosome encodes two protein isoforms (Figure 1A). The...
Ribosomal proteins located at the peptidyl transferase center, specifically ribosomal protein L26 (Villarreal and Lee, 1998; Marzouki et al., 1990), can regulate initiation of translation via interaction with elongation factor-2 (Nygard et al., 1987). Lee and Horowitz (1992) suggested that L26...
The extract is being prepared from mutant Escherichia coli cells having a mutation in the ribosomal protein S12 gene. In a preferred embodiment, the mutation is such a mutation as conferring a resistance or dependence to streptomycin on whereby the reading efficiency of mRNA codon on ribosomes ...
a single copy of RP genes.142In addition to RPs, several non-RP genes also contribute to the pathogenesis of DBA. Reduced translation of the key erythroid transcription factor GATA1,143increased degradation of the GATA1 chaperone HSP70,144or mutation in the RPS26 chaperone protein TSR2,145...
Research2MeVt0oaa0lrul7y.mgoeld8, Issue 10, Article R216 Open Access The ribosomal protein genes and Minute loci of Drosophila melanogaster Steven J Marygold*, John Roote†, Gunter Reuter‡, Andrew Lambertsson§, Michael Ashburner†, Gillian H Millburn†, Paul M Harrison¶, Zhan ...
Neither member of these 9 CRP gene pairs contains a nonsense mutation in the protein-coding region (data not shown), indicating that all 18 genes are potentially functional. Moreover, the low ratio of nonsynonymous to synonymous substitutions (KA/KS) between the members of each gene pair sugge...