Reverse transcriptase activity has been found in a type C virus isolated from a cell line from a patient with lymphoma which showed antigenic characteristics distinct from other mammalian type C viruses. These findings open several possibilities for determining the relationship of this virus to the ...
Noun1.reverse transcriptase inhibitor- an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV antiviral,antiviral agent,antiviral drug- any drug that destroys viruses NNRTI,non-nucleoside reverse transcriptase inhibitor- an antiviral drug used against HIV; binds di...
Reverse transcriptase activity has been found in a type C virus isolated from a cell line from a patient with lymphoma which showed antigenic characteristics distinct from other mammalian type C viruses. These findings open several possibilities for determining the relationship of this virus to the pa...
Related to reverse transcriptase: reverse transcription, Reverse transcriptase inhibitorsreverse transcriptase n. A polymerase that catalyzes the formation of DNA on an RNA template, found in the retroviruses and in certain other viruses, such as hepatitis B virus. American Heritage® Dictionary of the...
Reverse transcriptase and the phenomenon of reverse transcription have since been discovered in many other organisms, including DNA viruses (hepatitis B virus, caulimovirus), bacteria (Myxococcus xanthus, some clinical strains of E. coli B), yeast (Ty retrotransposon), fungi, invertebrates (copia-...
to be used both in clinical practice and in antiviral research. Reverse transcriptase (RT) inhibitors have an eminent place among the anti-HIV drugs, being constantly present from the beginning until today in the most commonly used antiviral regimens. This mini-review seeks to provide an up-to...
Serial passage of HIV-1 in CEM or MT-4 cell cultures in the presence of different HIV-1-specific reverse transcriptase (RT) inhibitors yielded mutant viruses which were resistant (i.e., 200- to 1000-fold less sensitive) to the homologous compounds. The RT of these mutant HIV-1 strains ...
In reverse transcription, RNA is “reverse-transcribed” into DNA. This process catalyzed by reverse transcriptase enzymes allows retroviruses including the human immunodeficiency virus (HIV) to use RNA as their genetic material. Reverse transcriptase enzymes have also found applications in biotechnology al...
Background:This study was a retrospective analysis of drug resistance mutations among HIV-1 strains prevalent in Silesia, Poland, from the origin of the epidemic to 2004. The investigations included both type and frequency of the reverse transcriptase in
HIV-1 protease (PR), reverse transcriptase (RT), and integrase (IN) variability presents a challenge to laboratories performing genotypic resistance testing. This challenge will grow with increased sequencing of samples enriched for proviral DNA such as dried blood spots and increased use of next-...