3-cinnamoyl-4-hydroxy-coumarin, hexachlorocoumarin, 7-acetoxy-coumarin or [1-(2-oxo-2H-1-benzopyran-3-yl)ethylidene]-hydrazinecarboxylic acid phenylmethyl ester or pharmaceutically acceptable salts thereof can be used to treat humans infected with one or more than one strain of a human immunodefi...
Reverse transcriptase, also called RNA-directed DNA polymerase, an enzyme encoded from the genetic material of retroviruses that catalyzes the transcription of retrovirus RNA (ribonucleic acid) into DNA (deoxyribonucleic acid). This catalyzed transcription is the reverse process of normal cellular transcrip...
Telomerase is a self antigen, making it possible that self tolerance imposes severe restrictions on our ability to generate effective anti-tumor immune responses in humans. In this article we review current studies on the antigenic and immunogenic properties of the human telomerase reverse transcriptase...
Publisher’s noteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. About this article Cite this article Zhou, H., Rauch, S., Dai, Q.et al.Evolution of a reverse transcriptase to mapN1-methyladenosine in human messenger RNA.Nat ...
Telomerase Reverse Transcriptase Regulates microRNAs MicroRNAs are small non-coding RNAs that inhibit the translation of target mRNAs. In humans, most microRNAs are transcribed by RNA polymerase II as long primary transcripts and processed by sequential cleavage of the two RNase III enzyme... T ...
Zinc status is difficult to evaluate in humans. Metallothionein gene expression is transcriptionally regulated by dietary zinc and thus could serve as an assessment parameter based on zinc-dependent function. We used semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) to establish th...
Rufer, N., et al., Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood, 2001.98(3): p. 597-603.Rufer N,Migliaccio M,Antonchuk J,Humphries RK,Roosn E,Lansdorp PM. Transfer of the human telomerase reverse...
Human telomerase reverse transcriptase as a critical determinant of telomerase activity in normal and malignant endometrial tissues Kyo S,Kanaya T,Takakura M,et al.Human telomerase reverse transcriptase as a critical determinant of telomerase activity in normal and malignant endometrial tissues[J].Int J...
The aim of the present work was to study telomere length and human telomerase reverse transcriptase (hTERT) level in acute myeloid leukemia and to detect if these parameters might be useful in providing insight into the clinical outcome of AML patients. ELISA technique was used to measure hTERT ...
Telomerase reverse transcriptase (TERT) expression and proliferation in canine brain tumours. Neuropathology and Applied Neurobiology 32, 662-673.Long S, Argyle DJ, Nixon C, et al. Telomerase reverse transcrip tase (TERT) expression and proliferation in canine brain tumours [ J ]. Neuropathol Appl...