Retrograde, transsynaptic signaling systems are a common feature of developing neural circuitry. The actions of growth factors, neurotrophins, and morphogen signaling molecules have been well described in the context of neuronal growth and survival. However, additional examples of retrograde transsynaptic ...
Endocannabinoids (eCBs) mediate short- and long-term depression of synaptic strength by retrograde transsynaptic signaling. Previous studies have suggested that an eCB mobilization or release step in the postsynaptic neuron is involved in this retrograde signaling. However, it is not known whether this...
ofsynapticstrengthbyretrogradetranssynapticsignaling.Previ- ousstudieshavesuggestedthataneCBmobilizationorrelease stepinthepostsynapticneuronisinvolvedinthisretrograde signaling.However,itisnotknownwhetherthisreleaseprocess occursautomaticallyuponeCBsynthesisorwhetheritisregulated ...
Luo L, Whelan SP, Sabatini B, Cepko CL (2011) Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Pr... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 110发表: 2011年 Spread of vesicular sto...
Injury of CNS nerve tracts remodels circuitry through dendritic spine loss and hyper-excitability, thus influencing recovery. Due to the complexity of the CNS, a mechanistic understanding of injury-induced synaptic remodeling remains unclear. Using micro
Endocannabinoids (eCBs) mediate short- and long-term depression of synaptic strength by retrograde transsynaptic signaling. Previous studies have suggested... L Adermark,DM Lovinger - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 219发表: 2007年 Retro...
of axonal transport of aggregated alpha-synuclein in vivo has not been shown. Therefore, the purpose of this study was to test the hypothesis that aggregated alpha-synuclein is propagated from cell-to-cell, and to determine whether this occurs using an anterograde or retrograde trans-synaptic mech...
Selective Retrograde Transsynaptic Transfer of a Protein, Tetanus Toxin, Subsequent to Its Retrograde Axonal Transport The non-toxic proteolytic C fragment of tetanus toxin (TTC peptide) has the same ability to bind nerve cells and be retrogradely transported through a syna... ME Schwab,KS Thoenen...
Injection of the non-toxic fragment C of tetanus toxin into the superior oblique muscle of the eye results in strong direct retrograde labelling of the motoneurons in the contralateral trochlear nucleus and clear transsynaptic labelling of neurons in the ipsilateral and contralateral vestibular nuclei....
autophago- somes to the soma is promoted by a protein complex comprising the autophagy protein LC3, the dynein activator p150Glued and the endocytic adaptor AP-2 (Fig. 7a), a protein hitherto thought to be exclusively involved in clathrin-mediated endocytosis24 and reformation of synaptic ...