We provide evidence that the worm orthologues of the synaptic adhesion molecules Neuroligin (NLG-1) and Neurexin (NRX-1) are required for the conductance of this retrograde signaling pathway. Despite wild type baseline transmission at cholinergic synapses, mutations in nlg-1 and nrx-1 completely ...
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling Tharkika Nagendran, Rylan S. Larsen, Rebecca L. Bigler, Shawn B. Frost, Benjamin D. Philpot, Randolph J. Nudo & Anne Marion Taylor Nature Communications volume 8, Arti...
TranssynapticTeneurinSignalinginNeuromuscularSynapseOrganizationandTargetChoiceTimothyJ.Mosca*,WeizheHong*,VardhanS.Dani,VincenzoFavalo..
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice Tomoyuki Yoshida Atsushi Yamagata Shuya Fukai Nature Communications (2021) Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α Maiko...
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In the present study, we have examined whether the ability of ProSAP2/Shank3 to interact with the cytoplasmic tail of Neuroligins functions to coordinate pre/postsynaptic signaling through the Neurexin-Neuroligin signaling complex in hippocampal neurons of Rattus norvegicus. Indeed, we find that ...
Ford A, Castonguay A, Cottet M, Little JW, Chen Z, Symons-Liguori AM, Doyle T, Egan TM, Vanderah TW, De Koninck Y et al (2015) Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain. J Neurosci 35:6057–6067. ...
Using the mammalian retina as a model system, we demonstrate that the HSPG member Pikachurin, released by photoreceptors, recruits a key post-synaptic signaling complex of downstream ON-bipolar neurons in coordination with the pre-synaptic dystroglycan glycoprotein complex. We further demonstrate that ...
Synapse formation is triggered by trans-synaptic interactions of cell adhesion molecules, termed synaptic organizers. Three members of type-II receptor protein tyrosine phosphatases (classified as type-IIa RPTPs; PTPδ, PTPσ and LAR) are known as presyn
In a complex NMJ organization centering on MuSK: (1) the Wnt non-canonical pathway through the Wnt-Lrp4-MuSK cysteine-rich domain (CRD)-Dishevelled (Dvl, scaffold protein) signaling acts to form AChR prepatterning with axonal guidance; (2) the neural agrin-Lrp4-MuSK (Ig1/2 domains) ...