Palladium on carbon (10% Pd/C) efficiently catalyzes the (retro-)Michael addition of activated methylene compounds 2ad, such as malononitrile (2b), to mono- and doubly activated styrenes 1ah to give the adducts 3al. The scope and limitations are described. The Knoevenagel condensation reaction ...
Studies on the reaction of some 1,5-ketodiesters/1,5-diketones with NaX (X = Cl/Br/I)/DMSO have shown that under microwave/thermal conditions, facile retro -Michael addition (RMA) reaction takes place instead of formation of the expected Krapcho products. Mechanistic studies have shown that...
单位代码10635学号11013316001159硕士学位论文-不饱和羰基化合物aza-Michaeladdition反应和Michael/retro-Claisencondensation串联反应的绿色合成研究论文作者:文静指导教师:蔡桂鑫副教授学科专业:有机化学研究方向:生物有机药物化学提交论文日期:016年04
第十七章 反合成分析(retro-synthesis)(修改)反合成分析一、基本概念 反合成分析 •Retrosynthetic(orantithetic)analysisisaproblemsolvingtechniquefortransformingthestructureofasynthetictarget(TGT)moleculetoasequenceofprogressivelysimplerstructuresalongapathwaywhichultimatelyleadstosimpleorcommerciallyavailablestartingmaterialsfor...
本研究基于绿色合成,发展了催化的α,β-不饱和羰基化合物分别与苯并咪唑类杂环水相aza-Michael加成反应以及与芳香b-二酮的Michael addition/retro-Claisen condensation串联反应,从而高效合成新型苯并咪唑衍生物和1,5-二羰基酯类化合物.苯并咪唑类结构单元作为一类重要的含氮杂环,广泛应用于药物,超分子和有机功能材料...
The Michael-Michael-retro Michael addition catalyzed by 9-amino-9-deoxyepiquinine was monitored and the major intermediates and catalyst in the catalytic cycle were detected and characterized using ESI-MS/MS for the first time. Some important isomeric intermediates including isomeric enamine and imine...