Amide-bond synthesis revisited Amide bonds are the key chemical connections within proteins, and form the basis of some of the most versatile and widely used synthetic polymers. Yet the established methods for amide formation are remarkably general and widely regarded as expensive and inelegant. In...
Recent advances in amide-bond-forming reactions are reviewed and summarized, highlighting the successful implementation of new synthetic methodologies and the limitations that need to be overcome to efficiently make the next generation of conventional sm
One of the most important reactions in organic chemistry-amide bond formation-is often overlooked as a contemporary challenge because of the widespread occurrence of amides in modern pharmaceuticals and biologically active compounds. But existing methods are reaching their inherent limits, and concerns ...