Amide bond forming reactions are critical for both polypeptide synthesis and medicinal chemistry. Most current approaches for amidation employ stoichiometric activating agents, but such methods are neither atom economical nor synthetically elegant. Catalytic approaches for amidation are potentially green and ...
One of the most important reactions in organic chemistry—amide bond formation—is often overlooked as a contemporary challenge because of the widespread occurrence of amides in modern pharmaceuticals and biologically active compounds. But existing methods are reaching their inherent limits, and concerns ...
Amide bond formation is an essential chemical reaction in all forms of life that is catalyzed by highly evolved biomolecular machinery. However, before ribosomes and specialized enzymes became capable of protein synthesis1,2, alternative, simple prebiotic routes to create peptide bonds in a spatiotemp...
Reinventing Amide Bond Formation 来自 dx.doi.org 喜欢 0 阅读量: 55 作者:Bode,W Jeffrey 摘要: The chemical synthesis of peptides and proteins has long relied on innovative inventions of amide-forming reactions. Our group has discovered and developed an amide-forming ligation reaction by the ...
Efficient Amide Bond Formation through a Rapid and Strong Activation of Carboxylic Acids in a Microflow ReactorAmideAminosäurenKontinuierliche ProzesseNaturstoffePeptideThedevelopmentofhighlyefficientamidebondformingmethodswhicharedevoidofsidereactions,includingepimerization,isimportant,andsuchamethodisdescribed...
The gas phase reactions of the substituted methyl cations, XCH 2 + (X = F, HO, and Cl), with formamide were investigated using ab initio calculations. Addition of the carbocations at the nitrogen atom of the amide bond yields "N adducts" that are less stable than the "O adducts" arisi...
The development of highly efficient amide bond forming methods which are devoid of side reactions, including epimerization, is important, and such a method is described herein and is based on the concept of rapid and strong activation of carboxylic acids. Various carboxylic acids are rapidly (0.5s...
Ester-mediated amide bond formation: A possible path to proto-peptides on the early earth The formation of polypeptides on the early Earth has been a long-standing problem in the field of prebiotic chemistry. Although it is generally accepted that amino acids were present on the prebiotic Earth...
nBu4NI-catalyzed unexpected amide bond formation between aldehydes and aromatic tertiary amines3 nBu4NI-catalyzed unexpected amide bond formation between aldehydes and aromatic tertiary amines. Mai W.-P,Song G,Yuan J.-W. et al. RSC Advances . ... W Mai,G‐ Song,J Yuan,... - 《Rsc ...
Amide bond formation and peptide coupling. Tetrahedron 61, 10827–10852 (2005). 2. Lanigan, R. M. & Sheppard, T. D. Recent developments in amide synthesis: direct amidation of carboxylic acids and transamidation reactions. Eur. J. Org. Chem. 2013, 7453–7465 (2013). 3. Pattabiraman, ...