Nutritional research in relation to aging can be divided into two categories: research aimed at determining the nutritional needs of the elderly so that they may lead a relatively productive existence until the
T. et al. Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1. J. Exp. Med. 195, 719–736 (2002). Article CAS PubMed PubMed Central Google Scholar Bieniasz, P. D. & Cullen, B. R. Multiple blocks to human ...
Tissue and organ biology are very challenging to study in mammals, and progress can be hindered, particularly in humans, by sample accessibility and ethical concerns. However, advances in stem cell culture have made it possible to derive in vitro 3D tissues called organoids, which capture some ...
Alzheimer’s disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder. As the exact cause of the disease is still unclear, the drug development is very challenging. This review encompasses the commonly used AD models involving var
(partial and total), medial meniscal tear, and ovariectomy. Surgical models involve the use of aseptic techniques to surgically induce OA in animals. The results are highly reproducible and progress rapidly. This makes surgical models an excellent choice for short-term studies. Yet, this invasive ...
Ionizing radiation induces apoptosis, cell cycle arrest, and DNA damage in germ cells. C.elegans, as a well-established model of ionizing radiation, has significant implications for the study of radiation effects in higher organisms. The research progress in ionizing radiation damage using C.elegans...
in biology and medicine for their wide range of applications, their potential toxicity, non-specific uptake and clearance, as well as the conditions during their production, currently limit their use in these fields. Many experiments in animal models and clinical studies are ongoing to prove that ...
Taylor K. Reporting the implementation of the Three Rs in European primate and mouse research papers: are we making progress? Altern Lab Anim. 2010;38:495–517. ArticleCASGoogle Scholar Okamura N, Hasegawa M, Nakoshi Y, Iino T, Sudo A, Imanaka-Yoshida K, et al. Deficiency of tenascin-...
and its decrease during aging may contribute to the cognitive decline of the aged brain. This Collection provides insight into the role, regulation, and age-associated reduction of adult neurogenesis, by gathering studies investigating this process in different model systems, ages, and brain regions....
A disease model is an animal or cells displaying all or some of the pathological processes that are observed in the actual human or animal disease. Studying disease models aids understanding of how the disease develops and testing potential treatment approaches. ...