et al. Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. EMBO Rep. 10, 887–893 (2009). CAS PubMed PubMed Central Google Scholar Tresini, M. et al. The core spliceosome as target and effector of non-canonical ATM signalling. ...
Earth’s life may have originated as self-replicating RNA, and it has been argued that RNA viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are defined by linear RNA genomes encoding an RNA-dependent RNA polymeras
Replication occurs in three major steps: theopening of the double helix and separation of the DNA strands, the priming of the template strand, and the assembly of the new DNA segment. During separation, the two strands of the DNA double helix uncoil at a specific location called the origin....
Understand and discuss DNA replication. Learn more about the function of the DNA replication fork, leading and lagging strand of DNA, and DNA supercoiling. Related to this QuestionWhat are the three components of DNA? What are the three major procedures of DNA Replication? What are the three ...
In another embodiment, this invention provides a method of DNA replication using PRD1 DNA polymerase and PRD1 terminal protein, which is characterized by the use of single- or double-strand DNAs having the above general formula as the replication origin....
PAIRADISE outputs a table of significant ASAS events (default significance is set to FDR <= 10%). Each row of the output table corresponds to a significant ASAS event and contains the following columns: ExonID: Gene name, chromosome number and strand, SNP name, genomic location, reference an...
For LOX1.2 and LOX1.3 the reference strand used for the determination of the minor allele was chosen to be consistent with dbSNP convention. Information on all SNPs from the SNP discovery effort has been submitted to the national dbSNP database. The subset of sequenced SNPs for genotyping in ...
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase Cells respond to DNA double-strand breaks by recruiting factors such as the DNA-damage mediator protein MDC1, the p53-binding protein 1 (53BP1), and the br... NK Kolas,JR Chapman,S Nakada,... - 《Science》 被引量:...
2. Results Human cells lacking p21 or wild-type p53 function escape cell cycle checkpoints after exposure to high doses of ionizing radiation (≥10 Gy) and execute mitosis despite carrying high levels of DNA radioproducts and chromosomal aberrations, leading to the creation of MNGCs [3,36]....