during DNA replication. Science, 2018. 361(6409): p. 1389-1392.11. Gan, H.Y., et al., The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands. Molecular Cell, 2018. 72(1): p. 140-+.想了解更多精彩内容，快来关注BioArt生物艺术 #热点引擎计划# ...
Stahl 2. Origins of replication 复制起始点 • 原核生物基因组为环形,有1个复制起始点 • 真核生物基因组庞大,有若干复制起始点 复制泡 3. Bidirectional 一泡双向 • DNA strands open at the origin, forming 2 Replication Forks (Y-shaped region) DNA在复制起始点解螺旋,形成2个复制叉(Y-形区) ...
2019年1月22日,来自伊利诺伊大学香槟分校的Andrei Kuzminov团队在PNAS上发表了题为Near-continuously synthesized leading strands in Escherichia coli are broken by ribonucleotide excision的研究文章,对DNA复制过程中前导链的不连续性问题做了详细的阐述。而源于这项工作的重要性,PNAS特邀华盛顿大学医学院的教授Peter M...
DNA replicationis the process of copying and duplicating aDNAmolecule. The process is carried out in asemiconservativeway. This means that the new DNA molecule will consist of two strands: one that is newly created and the other is the original strand. Importance of DNA Replication DNA carries ...
10. Petryk, N., et al., MCM2 promotes symmetric inheritance of modified histones during DNA replication. Science, 2018. 361(6409): p. 1389-1392. 11. Gan, H.Y., et al., The Mcm2-Ctf4-Polα Axis Facilitates...
19. Yu, C. et al. A mechanism for preventing asymmetric histone segregation onto replicating DNA strands.Science361, 1386-1389, doi:10.1126/science.aat8849 (2018). 20. Bellelli, R. et al. POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.Mol...
DNA (deoxyribonucleic acid) is a type of macromolecule known as anucleic acid. It is shaped like a twisteddouble helixand is composed of long strands of alternating sugars and phosphate groups, along with nitrogenous bases (adenine, thymine, guanine, and cytosine). DNA is organized into structur...
semiconservative replication, the two strands of the double helix separate during DNA replication, and each strand serves as a template from which the newcomplementary strandis copied; after replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. There...
DNA replication proceeds with continuous synthesis of the leading strand and discontinuous synthesis of the lagging strand. Yu etal. describe eSPAN, a method to measure relative amounts of proteins on the leading and lagging strands of r... C Yu,H Gan,J Han,... - 《Molecular Cell》 被引...
Powered by ATP hydrolysis, MCM steps away from its own loader, tracking along both DNA strands. Agata Butryn , Julia F. Greiwe & Alessandro Costa Article 16 January 2025 | Open Access Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability ...