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renal potassium (K) wastingChan CLin SHHalperin MLAm Soc Nephrol Ann Mtg -- Toronto
If a basic renal profile (Na, K, Cl, HCO3, urea, creatinine, Ca, PO4and albumin) suggests salt-wasting and electrolyte disturbance, the (Table 1) shows the next set of investigations to consider. An assessment of Conclusions This review by necessity has not included examples of all tubulo...
Hypokalemia may be caused by increased intracellular entry of potassium (e.g. with insulin, β-adrenergic agents, hematopoiesis), gastrointestinal losses, and renal potassium wasting (e.g. hyperaldosteronism, diuretics). Patients with chronic alcoholism often present with multiple electrolyte abnormalities...
The authors present histopathologic data on a 4 yr old white boy with renal potassium wasting and potassium depletion in a setting of Bartter's syndrome and renal tuberous sclerosis. The renal papilla and inner medulla contained a lesion characterized by intracellular, PAS positive, diastase resistant...
Focuses on the hyperaldosteronism and hypergranularity of the juxtaglomerular cells in renal hypertension. Data indicating that the hypokalemia and renal potassium wastage manifested as a function of a renal cation exchange mechanism probably influenced by aldosterone; Suggested procedures which might be hel...
[64]Hypokalemia in this condition is caused by renal potassium wasting.[65][66]Chronic alkaline urine, combined with hypercalciuria and hypocitraturia, leads to nephrocalcinosis and calcium phosphate stone formation. Appropriate potassium citrate therapy can correct metabolic acidosis, hypercalciuria, and...
Therefore, the ROMK gene must lie ⩾16 cM telomeric to the critical region and can be effectively excluded as a candidate for autosomal dominant isolated renal magnesium wasting. The physiology of renal magnesium handling has been studied mainly in the rat. Most reabsorption of magnesium appears...
K+wasting associated withBartter syndrome.15,16,17,18Moreover, disease resulting from inactivation ofNCCand the ClCchloride channelbeta subunitbarttin, anddiureticssuch asthiazideinhibitors of the NCC co-transporter that decrease NaCl reabsorption in the DCT, also cause renal K+wasting by this common...
Recently, we described a new syndrome in children with renal salt wasting mimicking Gitelman syndrome. The children initially presented in infancy with seizures and investigations into developmental delay later revealed ataxia and sensorineural deafness. This constellation of symptoms was not previously ...