The authors present histopathologic data on a 4 yr old white boy with renal potassium wasting and potassium depletion in a setting of Bartter's syndrome and renal tuberous sclerosis. The renal papilla and inner medulla contained a lesion characterized by intracellular, PAS positive, diastase resistant...
Recently, we described a new syndrome in children with renal salt wasting mimicking Gitelman syndrome. The children initially presented in infancy with seizures and investigations into developmental delay later revealed ataxia and sensorineural deafness. This constellation of symptoms was not previously ...
Isolated nephrocalcinosis due to compound heterozygous mutations in renal outer medullary potassium channel Identification of a monogenic etiology is possible in a proportion of patients with childhood-onset nephrolithiasis or nephrocalcinosis. Bartter syndrome (... P Khandelwal,J Sabanadesan,A Sinha,......
Data indicating that the hypokalemia and renal potassium wastage manifested as a function of a renal cation exchange mechanism probably influenced by aldosterone; Suggested procedures which might be helpful in diagnostically evaluating a patient with hypertension and hypokalemia....
This familial disease may represent congenital renal wasting of magnesium and potassium.doi:10.1111/j.1442-200X.1993.tb03047.xFUJIHIKO IWATADepartment of Pediatrics, Tobu Regional Hospital, Tokyo, JapanYOSHIO HANAWADepartment of Pediatrics, Tobu Regional Hospital, Tokyo, JapanHIROTADA TAKASHIMA...
+wasting associated with Bartter syndrome.15,16,17,18Moreover, disease resulting from inactivation of NCC and the ClC chloride channel beta subunit barttin, and diuretics such as thiazide inhibitors of the NCC co-transporter that decrease NaCl reabsorption in the DCT, also cause renal K+wasting ...
Renal regulation of potassium The cases discussed in this review have hyperkalaemia or hypokalaemia as part of the presentation so it will be helpful to review the physiology of potassium homeostasis in more detail. Around 65% of filtered potassium is reabsorbed in the proximal tubule where it...
9: 767-773 (1975) Glucose-6-phosphate dehydrogenase deficiency inner ear deafness Lightwood's syndrome renal tubular acidosis, bicarbonate wasting renal tubular acidosis, classic distal renal tubular acidosis, transient distal Persistent and Transient Distal Renal Tubular Acidosis with Bicarbonate Wasting E...
Renal tubular acidosis (RTA) is a well-recognized extraglandular complication of adult Sjögren syndrome (SS) but has been reported only rare... F.,Pessler,H.,... - 《Rheumatology》 被引量: 55发表: 2006年 Renal tubular acidosis and renal potassium wasting acquired as a result of hyper...
Inspection of the potassium channels on the array (Table 7) clearly identifies just four that are expressed at appreciable levels. Irk3, Ir, Irk2 and NCKQ are all both very abundant and highly enriched in tubule. Irk3 in particular is 80-fold enriched over the rest of the fly, implying...