Recent research has shown that exosomes secreted by human adipose mesenchymal stem cells (ASC-Exos) can benefit wound healing. To further explore the therapeutic potential of ASC-Exos, we investigated their effects on mitigating scar formation, and the underlying mechanisms of these effects. We ...
ANMCO POSITION PAPER: The cardiological clinical activities in the transition phase of the COVID-19 pandemic Infections by SARS CoV2 - COVID-19 became in a short time a worldwide health emergency. The present SARS-CoV-2 pandemic induced in a short time, an unprece... V Serafina,C Fur...
This study aimed to investigate different pathophysiological aspects of COVID-19 and post-COVID ILD in the non-acute phase using exploratory biomarkers reflecting tissue remodelling, wound healing, and neutrophil activity. A panel of biomarkers reflecting these different biological processes were measured...
Activation of MMPs is regulated by (i) the processing of their inactive precursors, known as pro-MMPs; (ii) their specific location; and (iii) their inhibition by endogenous or exogenous MMPs inhibitors. Pro-MMPs retain a cysteine in the propeptide domain linked to an atom of Zn+in the ca...
King TE, Bradford WZ, Castro-Bernardini S, Fagan EA, Glaspole I, Glassberg MK, Gorina E, Hopkins PM, Kardatzke D, Lancaster L, Lederer DJ, Nathan SD, Pereira CA, Sahn SA, Sussman R, Swigris JJ, Noble PW, Group AS (2014) A phase 3 trial of pirfenidone in patients with idiopathic...
Upon thrombin stimulation, PAR1 dimerizes with PAR4 during platelet activation. PAR4 amplifies the high intracellular Ca2+levels that support the late phase of platelet aggregation. The lack of a hirudin like domain in PAR4 makes it less sensitive to thrombin, therefore needing 10-fold higher thr...
[103]. Considering the finding that increased histone Kla in the late phase of M1 macrophage polarization drives an M2-like phenotype, which is characteristic of tumour-associated macrophages (TAMs) [21,101], an indirect role for Kla in cancer growth and proliferation has been proposed, and ...
The wound healing process, implemented by liver tissue in response to RFA, comprises local tissue reactions such as inflammatory cell infiltration and extracellular matrix (ECM) remodeling in the periablational rim as well as global alterations such as increased expression of inflammatory cytokines and...
One of the major limitations of human studies is that tendon biopsies are usually obtained when patients are symptomatic and therefore biopsy material is likely to represent chronic, rather than early phase processes. We previously suggested that matched subscapularis tendon from patients with full ...
[103]. Considering the finding that increased histone Kla in the late phase of M1 macrophage polarization drives an M2-like phenotype, which is characteristic of tumour-associated macrophages (TAMs) [21,101], an indirect role for Kla in cancer growth and proliferation has been proposed, and ...