Creating relevant cell models also comes down to having a talented team of scientists who are supported with cutting-edge machine learning technology. At Horizon, our teams include people with experience and a great knowledge of the ‘art’ of biology, and who know how to nurture cell lines. ...
However, there is a widening gap between natural-product researchers in countries rich in biodiversity and drug discovery scientists immersed in proteomics and high-throughput screening.doi:10.1016/S0165-6147(99)01346-2Alan L. HarveyTrends in Pharmacological Sciences...
In view of significant overlap between TCM and CMP as well as zhongyi, it is no surprise that the majority of conservation practitioners and scientists make no differentiation between these in their use of terminology. We here draw attention to the issue not as a criticism of any of the ...
These insights have provided scientists with a new opportunity for selective RNA targeting with small molecules, which can be tuned toward bioavailability and cell permeability. In this review, we discuss successes in targeting RNA tertiary and quaternary structures. In particular, we highlight diverse...
clinical-relevant intertumoral heterogeneity of NSCLCs driven by MET exon 14 skipping. Based on the molecular subtyping, subtype A was more sensitive to MET-TKIs, while subtype D was putatively resistant to MET-TKIs," said Dr. Han. "Of note, subtype C might be more vulnerable to ...
(2021) have investigated potential sources of SARS-CoV-2, raising important questions as to the origins of the virus being either naturally occurring or man-made. At the start of 2021, WHO sent a cohort of international scientists to undertake investigations into the origins of the virus. They...
"There is a need in the field to adopt clinically relevant models to study NSTEMI pathophysiology and reveal its functional differences with STEMI induction. This new model will facilitate the translation of future research in the field, enabling the discovery of new clinically relevant treatments for...
If you intend using humor in your talk to make people smile, you must know how to identify shared experiences and problems. Your humor must be relevant to the audience and should help to show them that you are one of them or that you understand their situation and are in sympathy with ...
Latest scientific news reported that American scientists David Julius and Ardem Patapoutian won the 2021 Nobel Prize for Physiology or Medicine, and their work was mainly on the discovery of the cellular receptors such as PIEZO and TRP channels in the skin, sensing temperature and touch which ...
This lack of a predictive in vivo model and no standardized in vitro tools have limited the options of pharmaceutical scientists to rationally design formulations for IM delivery. Here, we describe a novel, tractable in vitro model informed by dominant extracellular matrix (ECM) components present ...