Diabetes Care, 6 (1983), pp. 26-33, 10.2337/diacare.6.1.26 View in ScopusGoogle Scholar [41] A. Caselli, H. Pham, J.M. Giurini, D.G. Armstrong, A. Veves The forefoot-to-rearfoot plantar pressure ratio is increased in severe diabetic neuropathy and can predict Pathophysiology/Complic...
Leslie RD, Palmer J, Schloot NC, Lernmark A (2016) Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment. Diabetologia 59:13–20 CAS PubMed Google Scholar Li X, Cao C, Tang X, Yan X, Zhou H, Liu J, Ji L, Yang X, Zhou Z (2019) Prevalen...
Obesity is classified according to body mass index (BMI), which is divided into six different categories (see Table1). Obesity is an increasing worldwide health concern because excess weight gain is associated with an increased risk for several diseases, most notably cardiovascular disease, diabetes...
EMMs that are inherent to the body and act as signaling agents for metabolic pathways may provide a safe way to impact NASH's multifactorial pathophysiology. We designed a novel EMM composition comprising five amino acids and an amino acid derivative (LIVRQNac) that has been found to ...
the pathophysiology of OS is still poorly understood and the translation of novel drugs into the market has become stagnant. Due to the importance of the tumor microenvironment (TME) in the development of metastases and the growing interest in targeting TME-specific pathways for novel therapeutics ...
Diabetes No 2400 (41.1%) Yes 1560 (26.7%) Not recorded 1873 (32.1%) Coronary artery disease No 3352 (57.5%) Yes 608 (10.4%) Not recorded 1873 (32.1%) Hypertension No 3548 (60.8%) Yes 412 (7.1%) Not recorded 1873 (32.1%) Heart rate <60 189 (3.2%) 60–99 3936 (67.5%)...
L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 65, 732–741 (2009). Article CAS PubMed PubMed Central Google Scholar Levkovitz, Y. et al. A double-blind, randomized study of minocycline for the treatment of negative ...
These cytokines were reported to be the key factor of PGE2 and PGF2a production in uterine myometrial cells67–69, and the overproduction of uterine prostaglandins has been a widely accepted explanation for the pathophysiology of dysmenorrhea70,71. The most common and effective med- ical treatment...
and other studies reported that breast size is associated with breast cancer risk1and type II diabetes2. In addition, dysmenorrhea (menstrual pain) was associated with subsequent endometriosis3and deep infiltrating endometriosis4, which is a severe type of endometriosis. Furthermore, age-at-menarche ...
[76,207]. This low expression level in heterologous expression systems has initially slowed down the development of specific inhibitors for SGLT2 as therapeutic lead compounds for the treatment of diabetes. Since SGLT2 has been identified as the transporter that corresponds to the previously described...