Diabetes mellitus (DM) is a long-lasting metabolic non-communicable disease often characterized by an increase in the level of glucose in the blood or hyperglycemia. Approximately, 415 million people between the ages of 20 and 79years had DM in 2015 and this figure will rise by 200 million ...
Current treatment options for foot ulcers, a serious and prevalent complication of diabetes, remain nonspecific. In this Perspective, we present recent advances in understanding the pathophysiology of diabetic wound healing and the emergence of previously unidentified targets. We discuss wound dressings tai...
Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial Abnormal cardiac metabolism contributes to the pathophysiology of advanced heart failure with reduced left ventricular ejection fraction (LVEF). Glucagon-l... KB...
with the most advanced stages of HFrEF. Thus, the efficacy and tolerability of guideline-directed medical therapies in patients with the most advanced stages of HFrEF often remain unsettled, and this knowledge is of crucial importance in the planning and timing of consideration for referral for adv...
Advanced glycosylation end products in skin, serum, saliva and urine and its association with complications of patients with Type 2 diabetes mellitus Background: The accumulation of advanced glycation end products (AGEs) has a key role in the pathophysiology of diabetes complications. Comparison of AG...
ASSESSMENT OF PATHOPHYSIOLOGY OF VITAMIN D DEFICIENT PATIENTS- A TERTIARY CARE CENTRE STUDY Udita Singhal, Manoj Sareen, Pearly Sen Abstract View|Html View|Download PDF CURRENT EPIDEMIOLOGIC AND CLINICAL ASSESSMENT RELATING ZYGOMATIC BONE AND ZYGOMATIC ARCH FRACTURES- A 3 YEAR RETROSPECTIVE STUDY ...
Pathophysiology of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2011;9(4):223–33. Article PubMed Google Scholar Schinner C, et al. Defective desmosomal adhesion causes arrhythmogenic cardiomyopathy by involving an Integrin-alphaVbeta6/TGF-beta Signaling Cascade. Circulation. 2022;146(21):1610–...
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues. Mol Aspects Med. 2019;65:37–55. Article CAS PubMed Google Scholar Powell EE. Wong VW-S, Rinella M. Non-alcoholic fatty liver disease Lancet. 2021;397:2212–24. CAS PubMed Google Scholar Hagström H, Shang Y, ...
Understanding the intricate interactions between proteins and lipids is crucial for deciphering cellular processes. This chapter explores advanced techniques that shed light on these interactions. Cross-linking coupled with mass spectrometry offers a pow
Reactive aldehydes such as HNE, when excessively produced under oxidative stress conditions, exhibit cytotoxic effects and play key roles in the pathophysiology of diabetes mellitus through the involvement in both development and progression of the disease [119]. For example, increased protein carbonyl ...