Stimulation of serine protein kinase activity (referred to as S6 kinase) occurs within minutes of addition of nerve growth factor (NGF) to PC12 rat pheochromocytoma cells. This enzyme activity is not related to the cAMP-dependent protein kinase (protein kinase A) or the Ca2+- and phospholipid...
Simons.Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells.Cellular Signalling. 2004... PM Simons - 《Cellular Signalling》 被引量: 210发表: 2004年 mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes...
Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits. The mammalian 5'-AMP-activated protein kinase is a heterotrimer consisting of an alpha catalytic subunit and beta and gamma noncatalytic subunits, each of ... JR Dyck,G Gao,J Widmer,... - ...
A major limitation in studying the role of MELK as a protein kinase is that it is not known what controls its activity and that MELK expressed in mammalian cells seems to be inactive (5). This has prompted us to examine what determines the activity and substrate specificity of MELK, ...
Trostchansky, Regulation of protein kinase C by nitroarachidonic acid: impact on human platelet activation, Arch. Biochem. Biophys. 533 (2013) 55-61.Regulation of protein kinase C by nitroarachidonic acid: Impact on human platelet activation. Bonilla,L. et al. Archives of Biochemistry . 2013...
Transcriptional activity of p53, a central regulatory switch in a network controlling cell proliferation and apoptosis, is modulated by protein stability and post-translational modifications including phosphorylation and acetylation. Here we demonstrate
Protein kinase C has recently attracted considerable attention because of its importance in the control of cell division, cell differentiation, and signal transduction across the cell membrane. The activity of this enzyme is altered by several lipids such as diacylglycerol, free fatty acids, lipoxins,...
The cyclin-dependent protein kinase (CDK) encoded by CDC28 is the master regulator of cell division in the budding yeast Saccharomyces cerevisiae. By mechanisms that, for the most part, remain to be delineated, Cdc28 activity controls the timing of mitotic commitment, bud initiation, DNA replicat...
DNA-PKcs, which belongs to the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family, has a central role in the regulation of NHEJ9. In combination with IR or genotoxic chemotherapy, inhibition of DNA-PK kinase activity can improve cancer therapy4. There have been many ...
Protein kinase Cδ activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis. J Biol Chem 1999; 274: 3927–3930. Google Scholar Datta R, Kojima H, Yoshida K, Kufe D. Caspase-3-mediated cleavage of protein kinase Cδ in induction of apoptosis. J Biol Chem. 1997;...