定义(CH):JUN激酶活性(包括含量、比例)相关(升高或激活)的所有过程。【所以首先要了解:Jun kinase(Jun激酶,或JNK)】 同义词:"positive regulation of JUNK activity"、"stimulation of JNK activity"、"up regulation of JNK activity"、"up-regulation of JNK activity"、"GO:0043506,upregulation of JNK activit...
POSITIVE REGULATION OF PKB/AKT KINASE ACTIVITY BY THE VACUOLAR (H+)-ATPASE IN THE CANONICAL INSULIN SIGNALING PATHWAY: IMPLICATIONS FOR THE TARGETED PHARMOCATHERAPY OF CANCER. PhD Thesis 2014Sevag Kaladchibachi
Positive regulation of deoxycytidine kinase activity by phosphorylation of Ser-74 in B-cell chronic lymphocytic leukaemia lymphocytes. Cancer Lett. 2007; 253:68-73.Smal, C.; Van Den Neste, E.; Maerevoet, M.; Poire, X.; Theate, I.; Bontemps, F. Positive regulation of deoxycytidine kinase...
Thus, Lyn kinase activity appears to be directly regulated by CD148 and has a predominantly positive role during B1 BCR signaling, a function that cannot be compensated for by other SFKs. This positive function in B1 B cells is distinct from Lyn’s dominant negative regulatory role in B2 B ...
Here authors show that activation of the downstream WNK1 kinase causes water entry into the cells, which is essential for CD4+ T cell proliferation. Joshua Biggs O’May Lesley Vanes Victor L. J. Tybulewicz ResearchOpen Access21 Feb 2025 Nature Communications Volume: 16, P: 1857 Tissue ...
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase family member that plays a central role in cytokine- and stress-induced apoptosis by activating c-Jun N-terminal kinase and p38 signaling cascades. ASK1-induced apoptotic activity is up-regulated by tw...
Interestingly, when Cdk2 kinase activity is inhibited by the Cdk-specific inhibitor, p21Cip1, a block to mitosis occurs, and inactive Cdc2-cyclin B accumulates. This block occurs in the absence of nuclei and is not due to direct inhibition of Cdc2 by Cip. Importantly, this block to mitosis...
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr. Opin. Cell Biol. 12, 186–192 (2000). Article CAS Google Scholar Dorfman, K. et al. Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-...
The underlying mechanisms probably involve protein kinase C activation and TLR overexpression, with consequent inhibition of the neutrophil function and decreased phagocytosis (Gupta et al. 2007). There is growing evidence focused on particular populations (i.e., obese and/or diabetic patients and HIV...
We identify Cyclin G-associated kinase (GAK) and Protein Kinase C Delta (PRKCD) as regulators of PRKN-independent mitophagy, with both being dispensable for PRKN-dependent mitophagy and starvation-induced autophagy. We demonstrate that the kinase activity of both GAK and PRKCD are required for ...