Little is known about the regulation of late‐acting operons important for spore formation. C‐signaling has been proposed to activate FruA, which binds DNA cooperatively with MrpC to stimulate transcription of developmental genes. We report that this model can explain regulation of the fad...
Physiological Control and Regulation of the Rhodobacter capsulatus cbb Operons The genes encoding enzymes of the Calvin-Benson-Bassham (CBB) reductive pentose phosphate pathway in Rhodobacter capsulatus are organized in at least two o... GC Paoli,P Vichivanives,FR Tabita - 《Journal of Bacteriolo...
For example, the type III CRISPR/Cas-associated Csy4 protein from Pseudomonas aeruginosa has been used in bacteria to achieve predictable regulation of multigene operons by cleaving precursor mRNAs. The functionality of Csy4 has also been demonstrated in bacteria, archaea, and eukaryotes (Qi et al...
Abstract Gene expression and regulation may be viewed as a parallel parsing algorithm---translation from a genomic language to a phenotype. We describe a model of gene expression and regulation based on the operon model of Jacob and Monod. Operons are groups of genes regulated in the same way...
The combining of regulatory proteins with acceptor loci alters or prevents the movement of RNA polymerase along the operon and the transcription of the structural zone. This model gives a satisfactory explanation of a number of facts such as (1) the formation of giant D-RNA and R-RNA ...
The regulation-based approach uses such criteria as the number of regulated genes, e.g. more than 15 genes [33] or 10 operons [23]. Additional criteria are the number and types of co-regulators, the variety of conditions in which the regulatory interactions are invoked, etc. [34]. ...
In prokaryotes, a form of genetic regulation in which one operon codes for the production of an internal inducer that turns on one or more operons. In eukaryotes, a multistep model of genetic regulation involving mechanisms that interface with messenger ribonucleic acid formation, transport, and ...
Organisms determine the transcription rates of thousands of genes through a few modes of regulation that recur across the genome1. In bacteria, the relationship between the regulatory architecture of a gene and its expression is well understood for individual model gene circuits2,3. However, a broa...
Genome-scale metabolic networks (GSMs) are fundamental systems biology representations of a cell’s entire set of stoichiometrically balanced reactions. However, such static GSMs do not incorporate the functional organization of metabolic genes and their dynamic regulation (e.g., operons and regulons)...
1528 Accesses 100 Citations 3 Altmetric Metrics details Abstract In a breast tumor xenograft model, the MCT-1 oncogene increases the in vivo tumorgenicity of MCF7 cells by promoting angiogenesis and inhibiting apoptosis. Increases in the tumor microvascular density are accompanied by a strong ...