The operon model for regulatingbacterial geneswas first proposed by François Jacob and Jaques Monod using the negatively regulated lactose genes ofE. colias an example. Since then a vast number of bacterial genes, including those with activators as well as those with repressors, have been fitted...
The operon model for regulating bacterial genes was first proposed by François Jacob and Jaques Monod using the negatively regulated lactose genes of E. coli as an example. Since then a vast number of bacterial genes, including those with activators as well as those with repressors, have been...
The regulatory model provides several potential explanations for the existence of operons [15]. It has been argued that co-regulation could be evolved more easily by modifying two independent promoters than by placing two genes in proximity [10]. A counter-argument to this is that, for complex...
Fucose, a mucin degradation product, was suggested as a communi... Saif, Nehal A.,Hashem, Yomna A.,Amin, Heba M.,... - Microorganisms 被引量: 0发表: 2023年 Regulation of Gene Expression in the Tryptophan Operon of Escherichia coli INTRODUCTION The classic model of Jacob and Monod (1961...
Since the Jacob-Monod model was proposed, this negative control mechanism functioning between repressor and operator has been verified by direct isolation of the repressor and demonstration of its conditional affinity for operator both on purified DNA 2 and in in vitro systems for transcription and ...
Also, addition of lactose or IPTG to the binding reaction greatly decreases the affinity of the repressor to the operator sequence, directly confirming the Jacob and Monod model, which was proposed mainly on the genetic studies. lac repressor and most other bacterial repressors are dimeric ...
A model for the structure and expression of the colicin E1 operon is proposed in which the cea and lys genes are expressed from a single inducible promoter that is controlled by the lexA repressor in response to the SOS system of Escherichia coli. The imm gene lies between the cea and lys...
The model of operon structure proposed by Jacob and Monod invoked a group of contiguous genes regulated by a common promoter in bacteria1. The resulting polycistronic transcripts can be several kilobases (kb) long and encode several proteins usually associated with the same function or metabolic pat...
For simplicity, we will refer to this method as ProOpDB, given that it was our resource for the predictions over the model organisms we used for the cross-tool comparison. The second tool is called the Database of Prokaryotic Operons (Door)3 and was ranked as the second best operon ...
However, varied electron transfer pathways were proposed for iodate reduction with different electron donors in the model strain Shewanella oneidensis MR-1. Here, through a series of gene deletion and iodate reduction experiments, we discovered that the dmsEFABGH operon was essential for iodate ...