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The mTOR signaling pathway plays an essential regulatory role in the differentiation and function of both innate and adaptive immune cells. Considering the ... S Mafi,B Mansoori,S Taeb,... - 《Frontiers in Immunology》 被引量: 0发表: 2022年 Regulation of immune responses by mTOR. mTOR is...
Immunology Regulation of T cell responses by microRNAs EMORY UNIVERSITY Rafi Ahmed WuTuoqiUnderstanding the mechanisms underlying the generation of effector functions and immune memory by T cells is essential to the development of more effective vaccination strategies. Various molecular pathways involved in...
Innate immune cells have complex signalling pathways for sensing pathogens and initiating innate immune responses against infection. These pathways are tightly regulated at different levels, including by epigenetic regulators. In this Review, we discuss studies revealing the epigenetic mechanisms, as well ...
A central player in regulating responses to stress is the serine/threonine kinase mammalian target of rapamycin (mTOR). In many cancers, mTOR complex 1 (mTORC1) signaling is enhanced, even under conditions where such signaling should be suppressed. This article reviews some of the details that ...
Effects of IL-12 on the response and susceptibility to experimental viral infections. Effects of administered IL-12 on immune responses to viral infection were evaluated. IL-12-mediated effects during lymphocytic choriomeningitis virus (LCMV... JS Orange,SF Wolf,CA Biron - 《Journal of Immunology》...
PI3K/PTEN/AKT/mTOR signaling The PI3K/PTEN/AKT/mTOR pathway is another interesting candidate that may impact the host immune response (Fig. 1, Table 1). The expression of PD-L1, a pivotal negative regulator of T cell function, is associated with the activation of PI3K in breast and prostat...
After undergoing metabolic reprogramming, tumor cells consume additional glutamine to produce amino acids, nucleotides, fatty acids, and other substances to facilitate their unlimited proliferation. As such, the metabolism of glutamine is intricately
Targeting these metabolic pathways represents a novel means of regulating immune responses. Abstract Over the past decade, our understanding of T cell activation, differentiation and function has markedly expanded, providing a greater appreciation of the signals and pathways that regulate these processes....
and metabolic reprogramming in immune cells (Table1, Fig.2). For the close association with energy production, the reprogramming of glycometabolism and lipid metabolism has gained much attention in immunometabolism. Amino acid signals have also shown their important roles in regulating immune responses...