The types of T helper effector cells have been widely used as prototypes for immune responses. Thus we have a proinflammatory Th1 type, Th17 type, and pro-allergic Th2 type of the response. In addition, Th9 and Th22 types have been recently described. The Th3, Tr1, and Treg type of ...
Regulation of immune response and hepatic fibrosis by the cytotoxic effector molecules granzyme B and TRAIL in sclerosing cholangitis in mice M Kellerer,G Tiegs,K Neumann,... - 《Jahrestagung Der Deutschen Arbeitsgemeinschaft Zum Studium Der Leber》 被引量: 0发表: 2023年 Temporal transcriptome ...
The community of cells lining our airways plays a collaborative role in the preservation of immune homeostasis in the lung and provides protection from the pathogens and pollutants in the air we breathe. In addition to its structural attributes that provide effective mucociliary clearance of the low...
R. Regulation of immune responses by mTOR. Annu. Rev. Immunol. 30, 39–68 (2012). CAS PubMed Google Scholar Doedens, A. L. et al. Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen. Nat. Immunol. 14, 1173–1182 (2013). CAS PubMed Pub...
These data highlight the importance of MDSC in the prostate, and demonstrate the function of MDSC during a localized inflammatory response is restricted to the site of an ongoing immune response. 展开 DOI: 10.17077/ETD.QB7BM0EX 年份: 2011 ...
Generation of a soluble immune response suppressor factor (IRSF) by unstimulated leucocytes of healthy subjects. Supernatants derived from unstimulated cultures of mononuclear leucocytes obtained from healthy subjects contained a factor(s) which consistently suppresse... Lederman,M.,M.,... - 《Clinical...
We hypothesize that a number of genes in the Mtb genome inhibit innate immune effector cells. To identify such gene products, we developed an innate immune response colorimetric reporter assay in macrophages and dendritic cells (DCs) infected with a non-pathogenic strain, Mycobacterium smegmatis (...
The lipid-raft-accommodated supercomplex plays important roles for the functional cytokines, regulation of lymphocyte proliferation, and effector immune responses (Vamosi et al., 2004). In human HL- and NHL-derived cell lines, cholesterol depletion to disintegrate the lipid rafts leads to a down-...
The immune-inflammatory response is associated with increased nitro-oxidative stress. The aim of this mechanistic review is to examine: (a) the role of redox-sensitive transcription factors and enzymes, ROS/RNS production, and the activity of cellular an
Febrile temperatures boost the probability of an effective immune response by stimulating both the innate and the adaptive arms of the immune system. The pyrogenic cytokine interleukin-6 (IL-6) contributes to two phases of the febrile response: it elevates the core body temperature via thermoregulat...