Sun SC. Deubiquitylation and regulation of the immune response. Nat Rev Immunol. 2008;8(7):501–11.Sun SC ( 2008 ) Deubiquitylation and regulation of the immune response . Nat Rev Immunol 8 : 501 – 511Sun, S.C., Deubiquitylation and regulation of the immune response. Nat Rev Immunol...
We hypothesize that a number of genes in the Mtb genome inhibit innate immune effector cells. To identify such gene products, we developed an innate immune response colorimetric reporter assay in macrophages and dendritic cells (DCs) infected with a non-pathogenic strain, Mycobacterium smegmatis (...
R. Regulation of immune responses by mTOR. Annu. Rev. Immunol. 30, 39–68 (2012). CAS PubMed Google Scholar Doedens, A. L. et al. Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen. Nat. Immunol. 14, 1173–1182 (2013). CAS PubMed Pub...
In this review, we discuss current knowledge of the multiple roles of AhR signaling in T cells and dendritic cells (DCs) and its relevance for the regulation of the immune response in health and disease. AhR-Dependent Signaling Pathways When inactive, AhR is localized in the cytoplasm as part...
Immunotherapy strategies may target the exosomes reprogramming of immune cells involved in antigenic invasions. • A higher magnitude of immune activity can be obtained through the exosome activation of immune response communication. • The immune response mechanism can be triggered by the transfer of...
The immune-inflammatory response is associated with increased nitro-oxidative stress. The aim of this mechanistic review is to examine: (a) the role of redox-sensitive transcription factors and enzymes, ROS/RNS production, and the activity of cellular an
Of all the arachidonic acid metabolites, only prostaglandin E (PGE) has been shown to have a clear role in the regulation of cellular and humoral immune re
医学免疫学：13 immune regulation免疫调节 医学免疫学 第十七章免疫调节 免疫调节（immuneregulation）免疫应答过程中,各种免疫细胞与免疫分子相互促进和抑制,•形成正负作用的网络结构,并在遗传基因的控制下,完成免疫系统对抗原的识别和应答。不同水平的免疫调节 •基因水平：MHC•分子水平：抗原、抗体、免疫复合物...
The tumor microenvironment is created by the tumor and dominated by tumor-induced interactions. Although various immune effector cells are recruited to the tumor site, their anti-tumor functions are suppressed. Infiltrates of inflammatory cells present in human tumors are chronic in nature and are enr...
Febrile temperatures boost the probability of an effective immune response by stimulating both the innate and the adaptive arms of the immune system. The pyrogenic cytokine interleukin-6 (IL-6) contributes to two phases of the febrile response: it elevates the core body temperature via thermoregulat...