of immune function, including innate immune responses to viruses and bacteria, the development and activation of lymphocytes, and the maintenance of immunological tolerance.The substrate binding of some DUBs, s
The community of cells lining our airways plays a collaborative role in the preservation of immune homeostasis in the lung and provides protection from the pathogens and pollutants in the air we breathe. In addition to its structural attributes that provide effective mucociliary clearance of the low...
Outside the GALT, the intestinal LP and epithelium are the immune effector sites hosting the largest pool of lymphoid and myeloid cells in the body. The journey of immune cells to and within the intestinal mucosa is instructed by epithelial and mesenchymal cells that impact the retention of immu...
Here, we review the role of IL-10 on bacterial control during the course of Mtb infection, from early innate to adaptive immune responses. We propose that IL-10 is linked with the ability of Mtb to evade immune responses and mediate long-term infections in the lung....
Plant immune pathways In nature, plants are generally exposed to a complex environment with a range of organisms and microorganisms, including insects, bacteria, fungi, and viruses. All these challenges have important influences on many aspects of plant life, including growth, development, crop yield...
The tumor microenvironment is created by the tumor and dominated by tumor-induced interactions. Although various immune effector cells are recruited to the tumor site, their anti-tumor functions are suppressed. Infiltrates of inflammatory cells present in human tumors are chronic in nature and are enr...
Induction and maintenance of donor-specific allo-immune tolerance is dependent on the balance of effector T cells and regulatory CD4+T cells (Tregcells)1. The latter play an essential role in the development of long-term allograft acceptance2and tolerance3. Hence, establishing protocols for immunot...
MiRNA are small, evolutionary conserved, single-stranded, non-coding RNA molecules that bind target mRNA to prevent protein production by one of two distinct mechanisms. Mature miRNA is generated through two-step cleavage of primary miRNA (pri-miRNA), which incorporates into the effector complex RNA...
a process known as metabolic reprogramming.12We are going to summarize the key metabolic pathways and metabolic reprogramming in immune cells (Table1, Fig.2). For the close association with energy production, the reprogramming of glycometabolism and lipid metabolism has gained much attention in immun...
K. The hormesis principle of neuroplasticity and neuroprotection. Cell Metab. 36, 315–337 (2024). Article CAS PubMed Google Scholar Baird, L. et al. A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells. Redox Biol. 66, 102845 (2023). Article...