Humoral immunityHypoxia-inducible factor-1α (HIF-1α) has been implicated in the regulation of many genes responsible for aerobic glycolysis; however, the role of HIF-1α in B-cell metabolism has not been well defined. Here, we analyzed patterns of gene expression and oxygen consumption rates...
The humoral immune response requires germinal centers to produce high-affinity antigen-specific antibodies that counter pathogens. Numerous studies have provided a better understanding of how metabolic pathways regulate the development, activation and fu
The immune-inflammatory response is associated with increased nitro-oxidative stress. The aim of this mechanistic review is to examine: (a) the role of redox-sensitive transcription factors and enzymes, ROS/RNS production, and the activity of cellular antioxidants in the activation and performance of...
Kinetics of humoral immune response to the major structural proteins of the porcine reproductive and respiratory syndrome virus Arch. Virol., 141 (3–4) (1996), pp. 751-761 View in ScopusGoogle Scholar Loo and Gale, 2011 Y.M. Loo, M. Gale Jr. Immune signaling by RIG-I-like receptors ...
DCs are archetypal antigen presenting cells (APCs) and play a dominant role in linking innate and humoral immunity [164]. In physiological conditions, tissue-resident DCs drain to the lymph nodes and, thereafter, present self-antigens to T-cells, thereby maintaining immune tolerance [165]. Howev...
High dose cyclophosphamide treatment in mice facilitates the onset of EAMG and results in a selective suppression of the humoral response to AChR whereas the cellular response is enhanced. Specific immunosuppression of EAMG is achieved by using a nonmyasthenic, denatured AChR preparation which cross ...
1.Regulationofantigen Originationstageofimmuneresponse: •RouteofAgentranceaindividual •DosageofAg •Structuralcharacteristic:antigen competition 8 2.Regulationofantibody •Regulationofimmunecomplex:IgM, IgG •Regulationofidotype-anti-idiotype
Fésüs G, Dubrovska G, Gorzelniak K, Kluge R, Huang Y, Luft FC, Gollasch M: Adiponectin is a novel humoral vasodilator. Cardiovasc Res. 2007, 75: 719-727. Google Scholar Gao YJ, Lu C, Su LY, Sharma AM, Lee RM: Modulation of vascular function by perivascular adipose tissue: the...
critical cells for long-term humoral immunity, conduct active FAO and minimal glycolysis to achieve rapid proliferation, indicating different metabolic patterns from T cells.119The important roles of short-chain fatty acids in regulating immune functions in B cells have been reported, also indicating ...
et al. Coexpressed RIG-I agonist enhances humoral immune response to influenza virus DNA vaccine. J. Virol. 85, 1370–1383 (2011). CAS PubMed Google Scholar Lazear, H. M. et al. Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the ...