Humoral immunityHypoxia-inducible factor-1α (HIF-1α) has been implicated in the regulation of many genes responsible for aerobic glycolysis; however, the role of HIF-1α in B-cell metabolism has not been well defined. Here, we analyzed patterns of gene expression and oxygen consumption rates...
Studies over the past few years revealed important new insights regarding the regulatory mechanisms orchestrating the humoral type 2 immune response. This includes investigations on B-cell extrinsic signals, such IL-4 and IL-21, derived from different T-helper cell subsets or discovery of new ...
This work focuses on the impact of the cytokine network on the humoral immune response, as well as on its implications for the evolving field of cytokine-based medical therapeutics. Scientists interested in how cytokines regulate the production of antibody, and the selective expression of distinct ...
Studies of these proteins have shown unexpected roles in cytokine production by T cells and myeloid cells, T cell-dependent humoral immune responses, NK cell-mediated cytotoxicity, and NKT cell development. This review highlights recent findings that have improved our understanding of the roles of ...
The humoral immune response requires germinal centers to produce high-affinity antigen-specific antibodies that counter pathogens. Numerous studies have provided a better understanding of how metabolic pathways regulate the development, activation and fu
Humoral Regulation the coordination of physiological and biochemical processes effected through the body’s fluids (blood, lymph, interstitial fluid) by means of biologically active substances (metabolites, hormones, parahor-mones, ions) released by cells, organs, and tissues in the course of their ...
In contrast, SRBC-primed helper T cells cross-reacted with both GRBC and BRBC, but not with CRBC or TRBC, indicating a difference in the specificity of antigen recognition between the cellular and the humoral immune responses. 展开 DOI: 10.1084/jem.137.3.721 年份: 1973 ...
DCs are archetypal antigen presenting cells (APCs) and play a dominant role in linking innate and humoral immunity [164]. In physiological conditions, tissue-resident DCs drain to the lymph nodes and, thereafter, present self-antigens to T-cells, thereby maintaining immune tolerance [165]. Howev...
Immune metabolism regulation of the germinal center response The humoral immune response requires germinal centers to produce high-affinity antigen-specific antibodies that counter pathogens. Numerous studies have pr... SC Choi,L Morel - 《Experimental & Molecular Medicine》 被引量: 0发表: 0年 Regul...
Anaphylatoxin-mediated regulation of the immune response. I. C3a-mediated suppression of human and murine humoral immune responses The C3a fragment of the third component of complement was found to have immunosuppressive properties. C3a is capable of suppressing both specific and polyclonal antibody re...