Glucagon-like peptide-1(7-36)amide (GLP-1) is a secreted peptide that acts as a key determinant of blood glucose homeostasis by virtue of its abilities to slow gastric emptying, to enhance pancreatic insulin secretion, and to suppress pancreatic glucagon secretion. GLP-1 is secreted from L ...
Glucagon is a potent glucose-elevating hormone that is secreted by pancreatic α-cells. While well-controlled glucagon secretion plays an important role in maintaining systemic glucose homeostasis and preventing hypoglycaemia, it is increasingly apparent that defects in the regulation of glucagon secretion...
Through its various hormones, particularly glucagon and insulin, the pancreas maintains blood glucose levels within a very narrow range of 4–6 mM. This preservation is accomplished by the opposing and balanced actions of glucagon and insulin, referred to as glucose homeostasis. During sleep or i...
Moreover, insulin-resistant subjects displayed higher levels of Prevotella copri and Bacteroides vulgatus, which elevated the circulating levels of branch-chain amino acids (valine, leucine and isoleucine) and eventually impaired glucose homeostasis (Pedersen et al., 2016). Thus, modulating gut ...
Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes 2001; 50: 1562–1570. Article CAS PubMed Google Scholar Vilsboll T, Zdravkovic M, Le-Thi T, Krarup T, ...
Glucagon-like peptide 1 (GLP-1) is a gut hormone that broadly promotes glucose homeostasis through the regulation of islet hormone secretion, as well as he... D Sandoval - 《Appetite》 被引量: 52发表: 2008年 Functions of fibroblast growth factors (FGFs) in the nervous system - ScienceDirec...
Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans. Diabetes. 2014;63:4089–99. Article CAS PubMed PubMed Central Google Scholar García-Ruiz E, Reynés B, Díaz-Rúa R, Ceresi E, Oliver P, Palou A. The intake of high-fat diets induces the ...
Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. For many loci, however, the mechanisms through
Pancreatic β-cells play a major role as sensors and rectifiers of glucose homeostasis. Insulin, the main hormone that lowers blood glucose, is secreted from β-cells upon nutrient ingestion. To precisely decode signals reflecting the extracellular metabolic environment, β-cells have a metabolic sens...
GLP-1GLP-2The pre-proglucagon derived peptides, glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) are both involved in a wide variety of peripheral functions, such as glucose homeostasis, gastric emptying, intestinal growth, insulin secretion as well as the regulation of ...