例如,使T细胞表达肿瘤特异性的嵌合抗原受体(chimaeric antigen receptor,CAR-T),在对白血病的治疗中有极大的成功。但ACT疗法的局限性在于,改造后T细胞在被输回肿瘤病人体内通常使短寿命的,且不能够克服肿瘤对T细胞的抑制效应。当初始免疫T细胞识...
development of car-t cells for long-term eradication and surveillance of hiv-1 reservoir (2019).[10.1016j.coviro.2019.04.004] effector memory regulatory t cells were most effective at suppressing rankl but their frequency was downregulated in tibial fracture patients with tgf-β1 enhances sdf-1...
例如,使T细胞表达肿瘤特异性的嵌合抗原受体(chimaeric antigen receptor,CAR-T),在对白血病的治疗中有极大的成功。但ACT疗法的局限性在于,改造后T细胞在被输回肿瘤病人体内通常使短寿命的,且不能够克服肿瘤对T细胞的抑制效应。 当初始免疫T细胞识别到抗原或者肿瘤细胞时,CD8 T细胞增殖为短寿命的肿瘤杀伤T细胞(cytotoxic ...