The onset of pharmacological action of metoclopramide is 1 to 3 minutes following an intravenous dose, 10 to 15 minutes followingintramuscularadministration, and 30 to 60 minutes following an oral dose; pharmacological effects persist for 1 to 2 hours. ...
Onset: 1-3 min (IV, ); 10-15 min (IM); 30-60 min (PO) Duration: 1-2 hr regardless of route Peak serum time: IV, 15 min; PO, 60-120 min Distribution Protein bound: 30-40% Vd: 3.5 L/kg Metabolism Metabolized by liver ...
oral administration of metoclopramide may be initiated. However, if severe symptoms are present, therapy should begin with REGLAN Injection (metoclopramide injection) (IM or IV). Doses of 10 mg may be administered slowly by the intravenous route over a 1- to 2-minute period. ...