Time/action profile (effects on peristalsis) ROUTEONSETPEAKDURATION PO 30–60 min unknown 1–2 hr IM 10–15 min unknown 1–2 hr IV 1–3 min immediate 1–2 hr Contraindications/Precautions Contraindicated in: Hypersensitivity;Possible GI obstruction or hemorrhage;History of seizure disorders;Pheochr...
population may be increased among the elderly, women, and diabetics, it is not possible to predict which patients will develop metoclopramide-induced TD. Both the risk of developing TD and the likelihood that TD will become irreversible increase with duration of treatment and total cumulative dose....
In general, the incidence of adverse reactions correlates with the dose and duration of metoclopramide administration. The following reactions have been reported, although in most instances, data do not permit an estimate of frequency: CNS Effects Restlessness, drowsiness, fatigue, and lassitude may ...
4 times/day. Convert to PO when possible. Usual duration: 2-8 wk. IM Post-op nausea and vomiting 10 mg near the end of the procedure. Repeat 4-6 hrly when needed. Renal impairment: Moderate to severe: Reduce dose by at least 50% CrCl (ml/min) <40 Reduce dose by at least 50%C...