1 人赞同了该回答 alternative (alt) allele是effect allele reference (ref) allele是other allele 发布于 2023-09-23 23:28・IP 属地吉林 AI 总结 在ukbiobank中下载的SNP数据里,ref和alt哪个是effect allele? 已引用 8 位答主的内容 查看AI 回答 1 如何评价视频《县中学生现状:每天在校超 17 小时,...
alternative (alt) allele是effect allele reference (ref) allele是other allele
则指的是GWAS关联检测中的reference allele (non-risk 或者 non-effect),也就是效应量beta(或odds ratio)估计时的参考,概念上与上述ref与alt的组合无关,但为了保持统一性,近年来研究中关联检验的reference 也会与 reference genome保持一致,以避免混淆等。
Is the effect of TB1on lateral root branching direct or indirect? We observed that plants with two copies of the tb1-ref allele had an increased density of first order and second order lateral roots (LR) (Table 2). Mechanistically, a key first step in lateral root primordia initiation is...
( defined $col_idx{tumor_seq_allele1} or defined $col_idx{tumor_seq_allele2} ) or die "ERROR: At least one MAF column for Tumor_Seq_Allele must be defined!\n"; # Fetch all tumor-normal paired IDs from the MAF, doing some whitespace cleanup in the same step my $tn_idx = $col...
On the other hand, inactivation of mutant soxRS resulted in a slight increase in the susceptibility of LTH to several fluoroquinolone drugs, and the introduction of the mutant allele had no effect on antimicrobial susceptibility of LT2, indicating that constitutive expression of soxRS played a ...
Frequencies of 1.6% or more of the variant allele when compared with the reference allele30 are shown Both parkin and pink1 are known to genetically interact in Drosophila, and Parkin and p62 were shown to physically interact in mammalian cells.6 We therefore decided to test the role of Ref(...
allele-level studies in sweet orange: a case study on citrus Huanglongbing tolerance 原文链接:https://doi.org/10.1093/hr/uhac247 利用阶段基因组在等位基因水平上揭示柑橘黄龙病耐受性的分子机制 Integration of semi-in vivo assays and multi-omics data reveals the effect of galloylated catechins on ...
Divide the alternative allele depth of the first sample, by the total sequencing depth of the first sample, and see if that is below 0.25. But is the first sample really representative for all samples? Or what if the first sample is not HET_VAR but HOM_REF or HOM_VAR? Or am I mis...
The author also proposed that the more fundamental underlying mechanism dictating the processes of the inactivation of the p53 gene occurring through mutation of one allele, and loss of the other, is very likely the formation and accumulation of a large numbers of unrepaired pyrimidine dimers on ...