As a result, chemoselective cross-electrophile couplings between aldehydes and ketimines are achieved via umpolung reactivity of ketimines to furnish amino alcohols (44 examples with good to excellent yields). To illustrate the utility of the amino alcohol products, 1,2-dihydroindol-3-one-based ...
Iron-catalyzed cross-couplings in the synthesis of pharmaceuticals: in pursuit of sustainability. Angew. Chem. Int. Ed. 57, 11116–11128 (2018). Article CAS Google Scholar Mako, T. L. & Byers, J. A. Recent advances in iron-catalysed cross coupling reactions and their mechanistic ...
Organic chemistry Development of nickel-catalyzed asymmetric reductive cross-coupling of benzylic electrophiles CALIFORNIA INSTITUTE OF TECHNOLOGY Sarah E. Reisman... AH Cherney - Dissertations & Theses - Gradworks 被引量: 2发表: 2015年 Nickel-Catalyzed Reductive Couplings The Ni-catalyzed reductive coupl...
Now, a multicomponent reductive cross‐coupling involving an inorganic salt (sodium metabisulfite) for the straightforward construction of sulfones is disclosed. Both intramolecular and intermolecular reductive cross‐couplings were comprehensively explored, and diverse sulfones were accessible from the ...
Reductive couplings of aryl halides are of great significance in modern organic synthesis because the resulting biaryl skeletons are widely found in dyes, natural products, pharmaceutical compounds, and optoelectronic molecules1,2. As a result, considerable efforts have been devoted to the development of...
Suzuki–Miyaura cross-couplings for alkyl boron reagent: recent developments—a review Article Open access 11 August 2023 Transition-metal-free C(sp2)–C(sp3) cross-coupling of α-(pseudo)halo aliphatic ketones with boronic acids via a 1,4-metallate shift Article 03 August 2023 Oxidative...
Reductive couplings of 2-halopyridines without external ligand: phosphine-free nickel-catalyzed synthesis of symmetrical and unsymmetrical 2,2'-bipyridines. Reductive Coupling of 2-Halopyridines without External Ligand: Phosphine-Free Nickel-Catalyzed Synthesis of Symmetrical and Unsymmetrical 2,2'-Bipyridin...
Overall, RE is not as well studied as OA mainly due to instability of complexes in RE reactions. It is, however, becoming better understood and widely used mainly due to its applications in organic synthesis. Typical examples include Suzuki andNegishi couplingsand theHeck reaction. The pioneering...
Studies on the 1,2-migrations in Pd-catalyzed Negishi couplings with JosiPhos ligands the transmetalation step in direct competition with the intermediate beta-hydride elimination of the alkenyl Pd(II) species; (2) the structural features ... AT Lindhardt,TM G?Gsig,T Skrydstrup - 《Journal ...
reductive cross-couplingsphotochemistryelectrochemistrynickel catalysiscarbon-carbon formationsMetal-catalyzed cross-electrophile couplings have become a valuable tool for carbon-carbon bond formation.This minireview provides a comprehensive overview of the recent developments in the topical field of cross-electroph...