valuable, as itallows carboxylic acids to serve as ubiquitous, orthogonal, andreadily accessible cross-coupling partners in paradigms underdecarboxylative regimen. However, despite the profoundimpact on chemical synthesis, decarboxylative cross-couplingshave been a challenge, owing to high energy requirements...
redox neutralcross-couplingC–P bond formationC–Se bond formationaryl halidesDFT calculationsWe have achieved a nickel-catalyzed cross-coupling reaction via concerted paired electrolysis under mild reaction conditions.In this electrochemical transformation,the anodic oxidation of NiII to NiIII and cathodic...
1b). Nevertheless, both the Weinreb family of reactions and these elegant cross-coupling processes still rely on stoichiometric amounts of main group organometallics or organoboron reagents. Fig. 1 Examples for ketone synthesis in modern organic chemistry and hydroacylation method using secondary amides...
Here we report a flow-through redox-neutral electrochemical reactor (FRER) that effectively removes organic contaminants from hypersaline wastewaters via the chlorination–dehalogenation–hydroxylation route involving radical–radical cross-coupling. Bench-scale experiments demonstrate that the FRER achieves over...
palladiumThe intramolecular coupling of two C(sp3)H bonds to forge a C(sp3)C(sp3) bond is enabled by 1,4‐Pd shift from a trisubstituted aryl bromide. Contrary to most C(sp3)C(sp3) cross‐dehydrogenative couplings, this reaction operates under redox‐neutral conditions, with the CBr bond ...
the limitations associated with the use of noble metal catalysts and the formation of C(sp3)–S bonds in transition metal-catalyzed cross-coupling reactions. The research team began with the optimization of reaction conditions to identify the most effective catalyst, solvent, temperature, and ...
Here we report a flow-through redox-neutral electrochemical reactor (FRER) that effectively removes organic contaminants from hypersaline wastewaters via the chlorination–dehalogenation–hydroxylation route involving radical–radical cross-coupling. Bench-scale experiments demonstrate that the FRER achieves over...
The cross-over of Fc is also larger compared with the experiment at room temperature, which contributes to the decrease in capacity. In the third iteration, RFB-1.2, discharge potential cut-offs of −0.3 V and −0.5 V were tested, but no effect on the efficiencies or capacities was ...
Redox-neutral dehydrogenative cross-coupling of alcohols and amines enabled by nickel catalysisPresented herein is a facile and straightforward synthetic method for the construction of amides via Ni/NHC-catalyzed amidation of alcohols with amines. The strategy exhibits various advantages over existing ...
Metal-catalyzed Cross-coupling Reactions (Wiley-VCH, 2004). Scheffler, U. & Mahrwald, R. Recent advances in organocatalytic methods for asymmetric C–C bond formation. Chem. Eur. J. 19, 14346–14396 (2013). Article CAS Google Scholar Bornscheuer, U. T. et al. Engineering the third ...