Redox-Neutral Decarbonylative Cross-Couplings Coming ofAgeQun Zhao [b] and Michal Szostak* [a, b]Carboxylic acids represent quintessential substrates for organicsynthesis. [1] Diverse electrophilic and nucleophilic reactions ofcarboxylic acids form the foundation of daily research by prac-ticing organic ...
redox neutralcross-couplingC–P bond formationC–Se bond formationaryl halidesDFT calculationsWe have achieved a nickel-catalyzed cross-coupling reaction via concerted paired electrolysis under mild reaction conditions.In this electrochemical transformation,the anodic oxidation of NiII to NiIII and cathodic...
Contrary to most C(sp3)C(sp3) cross‐dehydrogenative couplings, this reaction operates under redox‐neutral conditions, with the CBr bond acting as an internal oxidant. Furthermore, it allows the coupling between two moderately acidic primary or secondary CH bonds, which are adjacent to an oxygen...
Here we report a flow-through redox-neutral electrochemical reactor (FRER) that effectively removes organic contaminants from hypersaline wastewaters via the chlorination–dehalogenation–hydroxylation route involving radical–radical cross-coupling. Bench-scale experiments demonstrate that the FRER achieves over...
and serve as practical thiyl radical precursors. This innovative use of thioformates circumvents the limitations associated with direct thiol use in cross-coupling reactions, such as catalyst deactivation and the requirement for harsh reaction conditions. Moreover, the broad substrate scope, including ...
Metal-catalyzed Cross-coupling Reactions (Wiley-VCH, 2004). Scheffler, U. & Mahrwald, R. Recent advances in organocatalytic methods for asymmetric C–C bond formation. Chem. Eur. J. 19, 14346–14396 (2013). Article CAS Google Scholar Bornscheuer, U. T. et al. Engineering the third ...
Here we report a flow-through redox-neutral electrochemical reactor (FRER) that effectively removes organic contaminants from hypersaline wastewaters via the chlorination–dehalogenation–hydroxylation route involving radical–radical cross-coupling. Bench-scale experiments demonstrate that the FRER achieves over...
For the prevention of redox shuttling of the neutral redox species, proton exchange membranes are required. Cation or anion exchange membranes can provide selective diffusions for the anionic or the cationic redox electrolytes, respectively. Often, polymers are applied for liquid, gel, or solid ...
1b). Nevertheless, both the Weinreb family of reactions and these elegant cross-coupling processes still rely on stoichiometric amounts of main group organometallics or organoboron reagents. Fig. 1 Examples for ketone synthesis in modern organic chemistry and hydroacylation method using secondary amides...
et al. Computationally assisted mechanistic investigation and development of Pd-catalyzed asymmetric Suzuki–Miyaura and Negishi cross-coupling reactions for tetra-ortho-substituted biaryl synthesis. ACS Catal. 8, 10190–10209 (2018). CAS PubMed PubMed Central Google Scholar Thomas, A. A. & ...