Nickel-Catalyzed Reductive CouplingsReductive couplingNickel catalysisElectrophilesSelectivityThe Ni-catalyzed reductive coupling of alkyl/aryl with other electrophiles has evolved to be an important protocol for the construction of C–C bonds. This chapter first emphasizes the recent progress on the Ni-...
Oxidative addition of anhydride (1) is followed by loss of carbon monoxide to generate homoenolateII. Oxidative capture of the alkyl radical formed Ni(III), which reductively eliminates to form Ni(I) intermediateIV. The Ni(I) intermediate is proposed to reduce the alkyl bromide2to furnish the...
Disulfides are widely found in natural products and find a wide range of applications in life sciences, materials chemistry and other fields. The preparation of disulfides mainly rely on oxidative couplings of two sulfur containing compounds. This strategy has many side reactions and other shortcoming...
The Ni-catalyzed reductive coupling of alkyl/aryl with other electrophiles has evolved to be an important protocol for the construction of C–C bonds. This chapter first emphasizes the recent progress on the Ni-catalyzed alkylation, arylation/vinylation, and acylation of alkyl electrophiles. A bri...
Nickel-catalyzed reductive cyclizations and couplings . Angew. Chem. Int. Ed. 43 , 3890–3908 (2004).J. Montgomery.Nickel-catalyzed reductive cyclizations and couplings. Angewandte Chemie International Edition . 2004Montgomery, J. (2004). Nickel-catalyzed reductive cyclizations and couplings. ...
Nickel-Catalyzed Carbon-Sulfur Bond Formation through Couplings of Aryl Iodides and Aryl Ethanethioatescross-couplingdiaryl sulfideethanethioatehomogeneous catalysisnickelA nickel-catalyzed reductive coupling between aryl iodides and aryl ethanethioates has been developed to afford diaryl sulfides.This method...
The development of one-pot conjunctive cross-couplings of C–C π-bonds yields greater atom economy, dramatically increases molecular complexity, eliminates sequential independent transformations, and enhances reaction simplicity. To advance the field of synthesis, 1,2-difunctionalization has emerged as a...
Enantioselective Metal-Catalyzed Reductive Coupling of Alkynes with Carbonyl Compounds and Imines: Convergent Construction of Allylic Alcohols and Amines The use of alkynes as vinylmetal pronucleophiles in intermolecular enantioselective metal-catalyzed carbonyl and imine reductive couplings to form allylic ......
The Ni(II) complexes with the highest steric bulk ligand afforded quasi quantitative yields in the C−S cross‐couplings using alkyl, heteroaryl thiols and aryl and heteroaryl bromides. Thus, the reductive elimination and oxidative addition are promoted by greater steric bulk (steric hindrance) ...
reductive cyclizationFor over 50 years, nickel catalysis has been applied in cycloaddition processes. Nickel-catalyzed reductive couplings and cyclizations, however, have only recently attracted a high level of interest. This group of new reactions allows a broad range of multicomponent couplings ...