Closer ana lysis revealed an accumulation of macrophages with upregulated expression of SPP1, TREM2 and CD9. The same large-scale shifts in cellular frequency and phenotype were identified in the HOMER (hypertension, obesity and mitral valve regurgitation) mouse model of AFib, with a prominent ...
Macrophages are a known source of CXCL10, but their specific source in the lung is poorly defined due to incomplete characterization of macrophage subpopulations. We recently developed a novel flow cytometric approach that discriminates resident alveolar macrophages from recruited exudative macrophages (Ex...
MACROPHAGESGLYCOLYSISImmunometabolism has emerged as a key area of focus in immunology and has the potential to lead to new treatments for immune-related diseases. It is well-established that glycolytic metabolism is essential for adaptation to hypoxia and for macrophage inflammator...
We have previously reported several regulatory and stimulatory effects of gastrodin-release system on M2-type macrophages. Polyurethane-nano hydroxyapatite (PU/n-HA) complexes in this context allow localized activity of gastrodin within a composite that is permissive for cellular orchestration, producing ...
When translated to an orthotopic nonhuman primate model, PPARγ-primed M2 macrophages immunosuppressed IL-1β, IL-6, TNF-α, MMPs to enable xeno-complex to effectively escape immune-mediated rejection and initiate graft-host synergistic integrity. These collective activities promoted the differentiation...
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. ...
When translated in vivo, the CD68+CD206+ M2 macrophages were recruited to the peripheral and intracavity of xeno-complex after RSG treatment, with a ratio of M2: M1>1 from 3 days to 3 weeks. These subsets alleviated inflammation both at implant sites and in the periphery system. When ...
We have recently reported that Kupffer cells consist of two subsets, radio-resistant resident CD68+ Kupffer cells and radio-sensitive recruited CD11b+ Kupffer cells/macrophages (Mφs). Non-alcoholic steatohepatitis (NASH) is characterized not only by hepatic steatosis but also chronic inflammation and...
1. Macrophages expand in human atrial disease Fig 1A:作者采集了5例control和7例持续性房颤患者的左房组织,进行了单细胞测序。 Fig 1B-C:一共得到41609个细胞,注释为6种细胞大群。在AFib心脏中,MP&DC比例扩增了近两倍,内皮和壁细胞比例降低,其他细胞比例保持稳定。
The algae cells/robots proceed to swim through the colon, thoroughly dispersing themselves throughout the organ. Cytokines in the colon then bind with the nanoparticles on the robots. This happens because the cytokines mistake the particles for macrophages, due to their coating of macrophage membranes...