Here we functionally analyzed the key amino acid residues located within receptor binding motif of RBD that may interact with human ACE2 and available neutralizing antibodies. The in vivo experiments showed that immunization with either the SARS-CoV RBD or SARS-CoV-2 RBD was able to induce ...
SARS - CoV - 2 Spike RBM (receptor binding motif), 450 - 473| 基本信息 更多信息 中文名称: 中文同义词: 英文名称: SARS - CoV - 2 Spike RBM (receptor binding motif), 450 - 473 英文同义词: SARS - CoV - 2 Spike RBM (receptor binding motif), 450 - 473 CAS号: 分子式: 分子...
Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies Article Open access 15 May 2020 Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig Article Open access 24 April 2020 Introduction Three ...
The invention provides a method for determining an amino acid sequence motif for a phosphorylation site of a protein kinase. In the method of the invention... LC Cantley,S Zhou 被引量: 85发表: 1996年 Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. G prot...
2e). One of these SNVs (rs201722399) is located within the CTCF motif that is strongly bound by CTCF in MCF7 cells, but loses its binding in FASR cells (highlighted in orange and in the zoomed-in view). Additionally, three other resistance-associated SNVs are present that are located...
Astructure-basedsignaturemotiffound inmanyhumanantibodiesindicates recogitionofthereceptor-bindingsiteof influenzavirushemagglutinin.These antibodiesarisefromdiversegermline originsandaffinitymaturationpathways andsuggestpotentialroutestoa universalfluvaccine. ...
Sequence analysis and structural alignment show that the ganglioside‐binding site (GBS) motif 'E…H…SXWY…G', which is highly conserved in BoNT/A, B, E (residue H is replaced by a K), Toxins 2017, ...
Moreover, using filter, solution, and BIAcore binding assays, we defined a PXXP motif within this region which exhibited a preference for the Lyn and Fyn kinase SH3 domains. Binding of Lyn SH3 domain to the membrane proximal region of PTPα required basic amino acids N-terminal to the PX...
Post-selective exchange of all pyrimidines against their 2'-fluoro analogs increased the aptamers stability significantly without compromising its affinity for the target protein. The resulting modified aptamer could be shortened to its minimal binding motif without loss of affinity. 展开 ...
5c). The largest chemical shift perturbation occurred at guanine-21, which is directly adjacent to the first adenine of the AATTY motif. This is in strong agreement with the crystal structure of the GR DBD–IL8κBRE structure, as the GR DBD makes two close interactions (2.7 Å) with ...