We have further demonstrated that mutations in the hexapeptide motifs impair binding of Bag-1L to the AR and differentially alter the androgen response of the receptor. The GARRPR sequence therefore defines a novel regulatory motif for modulating the activity of the AR through the BF-3 domain. ...
Regulation of androgen receptor-dependent transcription by coactivator MED1 is mediated through a newly discovered noncanonical binding motif. The Journal of biological chemistry. 2012; 287(2):858-870.Jin F, Claessens F, Fondell JD. Regulation of androgen receptor-dependent transcription by coactivator...
Demonstrating that this was not due to the nucleotide composition, those regions of the chromosome that have an ARE motif but no AR binding did not have the same type of mutations (Fig. 3a). When we shuffled chromosomal locations to match the nucleotide composition of ARBS and recalculated ...
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Functionally, AR and ER share many similarities in their signaling pathways, including the mechanism of receptor activation, as both receptors are activated through ligand binding83. ER and AR recognize similar sequences of DNA: where ER binds to 5'-AGGTCA-3', AR recognizes the 5'-AGAACA-3...
Here we globally mapped the AR binding regions in mouse caput epididymis in which AR is highly expressed. Chromatin immunoprecipitation sequencing indicated that AR bound selectively to 19,377 DNA regions, the majority of which were intergenic and intronic. Motif analysis showed that 94% of the AR...
Androgen receptor (AR) belongs to the steroid hormone receptor group of ligand-activated transcription factors in the nuclear receptor superfamily. AR mediates the action of physiological and exogenous androgens to regulate the expression of a network of
Discriminative DNA motif analysis of DHT-induced AR/GATA3 binding sites identified common (AR/PR/GR) steroid receptor response elements and more specific AR response elements as the predominant motifs, while GATA3 binding sites unaffected by hormone treatment predominantly contained GATA motifs (...
Jehle K, Cato L, Neeb A, Muhle-Goll C, Jung N, Smith EW, Buzon V, Carbo LR, Estebanez-Perpina E, Schmitz K, Fruk L, Luy B, Chen Y, Cox MB, Brase S, Brown M, Cato AC (2014) Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif. J Biol...
Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer 喜欢 0 阅读量: 39 作者:Urbanucci,Barfeld,S.,Kytölä,Itkonen 摘要: Global changes in chromatin accessibility may drive cancer progression by reprogramming transcription factor (TF) binding. In addition, ...