大家好,今天为大家分享一篇发表在ACS CentralScience上的文章,文章的题目是“Leveraging a Phage-Encoded Noncanonical Amino Acid: A Novel Pathway to Potent and Selective Epigenetic Reader Protein Inhibitors”,通讯作者是来自德克萨斯...
*注解: 将能识别特异性表观修饰并与其结合的蛋白喻为“读者或阅读器(readers)” 众所周知,小分子物质很难抑制蛋白质相互作用(Protein-Protein Interactions, PPI)。但由于PPI广泛存在及其生理重要性,因此发现和确认PPI药理学靶点就非常具有吸引力。目前虽有一些文献报道了PPI小分子抑制剂的例子,但仅有少数具有临床意义。
By binding to acetylated proteins, acetyl reader proteins can influence gene expression, protein stability, and other cellular functions. 中文回答: 蛋白质乙酰化是一种常见的后转录修饰,对调节各种细胞过程起着至关重要的作用。组蛋白的乙酰化,负责将DNA包装成染色质,特别重要于基因表达的调控。识别和结合乙酰...
Together, our results demonstrate that MRG702 acts as a reader protein of H3K4me3 and H3K36me3 and deciphers the H3K36 methylation information set by SDG725. Therefore, the role of MRG702 in the BR pathway and in controlling flowering time in rice is to function as a reader protein to...
Protein folding has become a tractable problem with the significant advances in deep learning-driven protein structure prediction. Here we propose FoldPAthreader, a protein folding pathway prediction method that uses a novel folding force field model by
Acetylation dynamics occur upon DNA damage in part to regulate chromatin and BRD protein interactions that mediate key DDR activities. In cancer, DDR and acetylation pathways are often mutated or abnormally expressed. DNA damaging agents and drugs targeting epigenetic regulators, including HATs, HDACs,...
This work provides the first functional characterization of an m6A reader protein and a main biological function of the m6A modification on mRNA, which is to alter the distribution and stability of mRNAs. Kim Baumann ORIGINAL RESEARCH PAPER Wang, X. et al. N6‑methyladenosine-dependent...
Out of three possible mechanisms (that should always be considered in the interpretation of any protein–ligand system), that is, solute– solute interactions, desolvation of ligand (in this case Kme3) and desolvation of protein (in this case aromatic cage), that govern the recognition of Km...
The aggresome is a key outlet for the unfolded protein respons... J. Amengual,M Lombardo,Kelly M. Zullo,... - 《Blood》 被引量: 1发表: 2015年 加载更多来源期刊 Genome biology 研究点推荐 Histone lactylation ocular melanoma therapy ocular melanoma ...
6-methyladenosine (m6A) and its associated reader protein insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) are involved in tumor initiation and progression via regulating RNA metabolism. This study aims to investigate the biological function and clinical significance of IGF2BP3 in gas...