SOX9 is an astrocyte-specific nuclear marker in the adult brain outside the neurogenic regions. J. Neurosci. 37, 4493–4507 (2017). Article CAS PubMed PubMed Central Google Scholar Wanner, I. B. et al. Glial scar borders are formed by newly proliferated, elongated astrocytes that interact...
(PET) and novel PET tracers, like 11C-deuterium-L-deprenyl (11C-DED) and (S)-(2-methylpyrid-5-yl)-6-[(3-[18F]fluoro-2-hydroxy)propoxy]quinoline (18F-SMBT-1), which bind to the reactive astrocyte marker monoamine oxidase B (MAO-B) (Carter et al., 2012; Harada et al., 2020)...
a, Transcriptomic profiling of human cortex samples showing the expression levels of reactive astrocyte marker genes (n = 3). b, KEGG enrichment analysis showing upregulation of reactive astrocyte-related pathways in TLE patients. c, Immunofluorescence detection of GFAP intensity in TLE patients ...
A single-nucleus RNA sequencing dataset encompassing normal, pathological aging, and Alzheimer’s disease brains [50] was reanalyzed here. The cluster containing astrocyte nuclei was identified based on expression of astrocyte-specific marker genesSOX9,GFAP, andALDH1L1(Fig.1a–d) and extracted for ...
Unlike the induced model, the congenital model displayed neuroinflammation and upregulation of several specific reactive astrocyte markers: GFAP; a Pan-reactive astrocyte marker, SERPINA3N; an A1 marker, and post-synaptic density 95 protein (PSD95); an A2-like marker (Table 1) [112]. These ...
Immunocytochemical characterization of a new marker of fibrous and reactive astrocytesKey words: Mab 6.17Reactive astrocyteDiencephalonSpinal cordConfocal microscopyUltrastructureRat (Sprague Dawley)A specific monoclonal antiserum (Mab 6.17) inducing a strong immunostaining of the neuromuscular junction has been ...
(n = 6/per group).Then, brain sections from CCI mice were immunostained with anti-BDNF, anti-NeuN (a marker of mature neuron), anti-GFAP(a marker of reactive astrocyte), anti-Iba-1 (a marker of microglia), and anti-CD31 (a marker of endothelial cell) antibodies to identify ...
An Astrocyte-specific antigen recognized by monoclonal antibody J1-31 is a more intense marker for proximal reactive astrocytes in lacerated rat spinal cor... SK Malhotra,M Svensson,H Aldskogius,... - 《Brain Research Bulletin》 被引量: 130发表: 1993年 Induction of astrocyte differentiation by...
(either GFAP+or 3PGDH+: a pan-astrocyte marker28,29,30) within the ischemic penumbra (Fig.5a). LAMP2 signals in astrocytes also peaked at 7 days and lasted for at least 14 days after MCAO (Fig.5b). Conversely, increased of Galectin-3 and CD68 in Iba1+microglia peaked at 3 days ...
No cells expressing A2 cassette transcripts were C3-positive, validating C3 as an appropriate marker for visualizing A1 astrocytes in disease. Segments of pie charts represent relative amounts of each subtype of astrocyte (control or reactive). Extended Data Figure 11 Additional markers for reactive ...