Transcriptomic studies in human patients and disease models have revealed the co-existence of many putative reactive sub-states of astrocytes. Inter-disease and even intra-disease heterogeneity of reactive astrocytic sub-states are well established, but the extent to which specific sub-states are ...
Transcriptomic studies in human patients and disease models have revealed the co-existence of many putative reactive sub-states of astrocytes. Inter-disease and even intra-disease heterogeneity of reactive astrocytic sub-states are well established, but the extent to which specific sub-states are ...
Reactive astrocytes are prominent in the cellular response to spinal cord injury (SCI), but their roles are not well understood. We used a transgenic mouse... Faulkner,R J. - 《Journal of Neuroscience》 被引量: 2071发表: 2004年 Reactive Astrocytes as Therapeutic Targets for CNS Disorders Reac...
Herein, we discuss emerging evidence that substantiates two functional roles for LCN2 in cancer: promotion of the epithelial-to-mesenchymal transition (EMT... JJ Rodvold,NR Mahadevan,M Zanetti - 《Cancer Letters》 被引量: 121发表: 2012年 Transcriptomic analysis of an in vitro murine model of...
Recent evidence indicates that Gal-1 is involved in the proliferation of adult neural progenitor cells in neurogenic regions during adulthood. However, localization and functional roles of Gal-1 in the adult spinal cord have not been clarified.Here, we investigated the spatio-temporal profile of ...
sufficient for the induction and long-term maintenance of reactive astrocytes. Importantly, its inhibition blunts astrocyte reactivity, reduces amyloid deposition, improves spatial learning and restores synaptic function in AD mouse models, revealing that reactive astrocytes have mostly deleterious roles in ...
Astrocytes play a critical role in the development and homeostasis of the central nervous system (CNS). Astrocyte dysfunction results in several neurological and degenerative diseases. However, a major challenge to our understanding of astrocyte physiolo
Through sequencing, we explored the roles of a differentially expressed circRNA in mice after SCI, circGla, on inflammation and recovery of SCI. Methods The T8–T10 SCI model was established in C57BL6 mice. HE staining and RT-qPCR verified circGla upregulation results after injury obtained ...
A. Emerging roles of astrocytes in neural circuit development. Nat. Rev. Neurosci. 14, 311–321 (2013). Article CAS PubMed PubMed Central Google Scholar Liddelow, S. A. & Barres, B. A. Reactive astrocytes: production, function, and therapeutic potential. Immunity 46, 957–967 (2017)....
Mounting evidence indicates that DNA damage and telomeres attrition play important roles in cardiac aging and disease18,30. SCIENTIFIC REPORTS | 4 : 7425 | DOI: 10.1038/srep07425 6 www.nature.com/scientificreports Indeed, fifth-generation telomerase KO mice display severely reduced telomere length ...