For more than 20 years Nolato has been a pioneer, helping customers develop and manufacture extremely small components for critical medical applications. In addition to a wide range of plastic engineering resins, we are experienced in micromolding high-performance materials such as PEEK, PSU... ...
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Merck is currently working with health authorities to include these OS data in the full KEYTRUDA prescribing information. Merck has a broad clinical development program in RCC across multiple settings, including adj...
The Toolkit help the patient be part of this process. As you fill out the form, think through the problems which concern you. Then you can discuss them well with the medical team. Use it during the appointment so your questions are addressed. After the appointment, it reminds you what was...
Talk with other patients, parents, and caregivers dealing with this rare form of kidney cancer. About Smart Patients Smart Patients is an online community for patients and families affected by a variety of illnesses. Here you can learn at your own level about scientific developments related to yo...
Crystals appeared in 1 day and rapidly grew to full size. The 1.31 Å native data were collected at 100 K on beamline 19ID at the Advanced Photon Source (Argonne National Laboratory, Chicago, IL, USA). The data sets were processed using the HKL3000 package (HKL Research Inc., ...
Full size image To test the relevance of these findings in renal tumours themselves, we next performed HIF-1β ChIP-qPCR analysis of each of the HIF-binding sites that overlapped or interacted with a RCC-susceptibility locus, using primary cultures of tumour and normal cells explanted from a ...
Full size image In summary, exogenous serine/glycine deprivation inhibits the proliferation and migration of RCC cells. Exogenous serine/glycine deprivation in RCC cells induced the autophagy‒lysosome pathway and affected autophagic flux When cells are under stress or nutrient deficiency, they form aut...