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Full size image The above findings confirm that RCC-associated polymorphisms are significantly enriched at cis-acting elements mediating the HIF transcriptional output, as defined by direct overlap with ChIP-seq signals for HIF binding. Although the entirety of cis-acting sequences affecting the HIF ...
The main feature of this form of regulated cell death is LMP. The galectin puncta assay is considered as a sensitive method for detecting LMP [29]. Strong galectin punctate fluorescence and its colocalization with LAMP1 were detected, resulting in the translocation of the cathepsins to the ...
This work was supported by the following grants to YY including: National Natural Science Foundation of China (Key Grants 81430056, 31420103905, 81301801 and 81621063), National Key Research and Development Program of China (Grant 2016YFA0500302), Beijing Natural Science Foundation (Key Grant ...
For that purpose different stiffness properties of the foundation rock are assumed, which cover the whole range of soft to stiff rock. The results show, that the stresses in the dam due to water load and gravity load do not depend much on the foundation stiffness; however, the ...
Full size image RCC2 protein folds as a seven-bladed propeller structure with a unique β-hairpin To better understand the mechanism by which RCC2 inactivates Rac1, we conducted structural biology studies. We first analyzed the structure of RCC2 by solving the crystal structure of a truncated ...
It is well known that RalA, a small GTPase, produces an effect by interacting with its downstream effector proteins such as RalBP1 and changing its GTP form to a GDP form.Citation18 To further investigate the interaction between RCC2 and RalA, a RalA pull-down assay was performed to detect...
This work was supported by National Natural Science Foundation of China (No. 81802657), Public Technology Research Projects of the Science Technology Department of Zhejiang Province (No. 2018C37109), Grant from Zhejiang Medical association (No. 2013zyc-A138) and Technology Research Projects of the...
For that purpose different stiffness properties of the foundation rock are assumed, which cover the whole range of soft to stiff rock. The results show, that the stresses in the dam due to water load and gravity load do not depend much on the foundation stiffness; however, the deformations ...
In this paper, the triaxial compressive test and split Hopkinson pressure bar (SHPB) experimental results for RCC are introduced as an experimental foundation. Parameter calibrations and modifications in terms of the strength yield surface, the strain rate effect and the failure criterion for the ...