Some cancer cells are more dependent on exogenous serine/glycine than endogenously synthesized serine/glycine. However, the function and underlying mechanisms of exogenous serine/glycine in renal cell carcinoma (RCC) remain unclear. Methods We conducted a comprehensive assessment of RCC progression under ...
Serine/glycine are critical for the growth and survival of cancer cells. Some cancer cells are more dependent on exogenous serine/glycine than endogenously synthesized serine/glycine. However, the function and underlying mechanisms of exogenous serine/gl
For years, the standard of care for early stage kidney cancer has been to remove the tumour surgically, sometimes with the entire kidney–either a partial or full nephrectomy. That was the end of treatment and the beginning of surveillance to watch for any signs of recurrence. (And early ...
“Results from KEYNOTE-564 show that pembrolizumab as adjuvant therapy significantly improved overall survival by 38% compared to placebo, becoming the first ever Phase 3 adjuvant trial to show improved survival for...
Display full size RCC2 Knockdown Inhibits Cell Migration and Invasion To investigate the motility of gastric cancer cells after RCC2 knockdown or overexpression, migration and invasion assays were performed. The migration assay showed that the SGC-7901 and MGC-803 cells migrated less and that fewer...
Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults [1]. RCC begins in the renal tubule epithelial cells, which are essential for blood filtration and urine production. RCC has three primary subtypes: clear cell RCC (ccRCC), chromophobe RCC, and papillary RCC [2...
8–17 www.nature.com/onc OPEN ORIGINAL ARTICLE RCC2 is a novel p53 target in suppressing metastasis C Song1, L Liang1, Y Jin, Y Li, Y Liu, L Guo, C Wu, C-H Yun and Y Yin RCC2 (also known as TD60) is a highly conserved protein involved in prognosis in colorectal cancer. Ho...
Full size image Full size image Overlap between cancer-susceptibility loci and HIF-binding sites in different cancer types Full size image Sub-threshold RCC-susceptibility loci associated with RCC are enriched for HIF-binding sites in RCC cells ...
Full size image Discussion Metastasis is a complex process that involves multiple steps, leading to therapy failure and cancer death. p53 is known to control transcription of genes that are involved in metastasis pathways, including cell adhesion, motility, invasion, epithelial–mesenchymal transition, ...
Full size image Human clinical sample analysis for TWIST1 expression in the ccRCC versus para-tumor non-cancerous tissues Mechanism dissection of how AR alters TWIST1 expression: via modulating the lncRNA-TANAR expression Fig. 3: Mechanism dissection of how AR can increase TWIST1 expression: via...