Short-interfering RNAs suppress gene expression through a highly regulated enzyme-mediated process called RNA interference (RNAi). RNAi involves multiple RNA-protein interactions characterized by four major steps: assembly of siRNA with the RNA-induced silencing complex (RISC), activation of the RISC, ...
Artificial RNA translation modulation usually relies on multiple components, such as RNA binding proteins (RBPs) or microRNAs (miRNAs) for off-switches and double-inverter cascades for on-switches. Recently, translational circular RNAs (circRNAs) were de
Rational siRNA design for RNA interference. Rational Expectations and the Theory of Price Movements A Behavioral Model of Rational Choice A Behavioral Model of Rational Choice A Behavioral Model of Rational Choice A BEHAVIORAL MODEL OF RATIONAL CHOICE ...
Rational siRNA design for RNA interference. Short-interfering RNAs suppress gene expression through a highly regulated enzyme-mediated process called RNA interference (RNAi). RNAi involves multiple R... A Reynolds,D Leake,Q Boese,... - 《Nature Biotechnology》 被引量: 4685发表: 2004年 The Ratio...
Fig. 1. Advanced optical imaging for the rational design of nanomedicines. A) Simplified nanoparticle (NP) discovery workflow to find a suitable or promising NP candidate for a given target diseased cell. B) How Advanced optical microscopies can be integrated in different steps of the NP develop...
siRNA delivery systems for cancer treatment With increasing knowledge on the molecular mechanisms of endogenous RNA interference, small interfering RNAs (siRNAs) have been emerging as innovative nucl... YK Oh,TG Park - 《Advanced Drug Delivery Reviews》 被引量: 761发表: 2009年 Design and ...
Now well-documented in mammals, RNAi results in gene suppression by cleavage or translational attenuation of target mRNA using small interfering RNA (siRNA) or short hairpin RNA (shRNA), respectively, as the functional intermediates in a highly coordinated protein :RNA complex known as RISC. ...
Rational siRNA Design for RNA Interference: Optimizations for Therapeutic Use and Current Applicationsbioinformaticoptimizationtomographycaenorhabditis eleganscarcinomadoi:10.1002/9783527620982.ch10Anastasia KhvorovaQueta BoeseWilliam S. MarshallJohn Wiley & Sons, Ltd...
Small interfering RNA (siRNA) therapy has significant potential for the treatment of myriad diseases, including cancer. While intravenous routes of delivery have been found to be effective for efficient targeting to the liver, achieving high accumulations selectively in other organs, including lung ...
We have observed that short RNAs that are long enough to serve as Dicer substrates (D-siRNA) can often evoke more potent RNA interference than the corresponding 21-nt siRNAs; this is probably a consequence of the physical handoff of the Dicer-produced siRNAs to the RNA-induced silencing ...