In the current study, an increase in COMP, MMP1, and MMP13 in the knees of rats with OA was observed, and was reversed by combining curcumin with swimming for 4 weeks. The fact that inflammation results in the activation of the MMPs such as MMP2, MMP3, MMP9, and MMP13, which ...
The collagenase matrix metalloprotease 2 (Mmp2) and the mast cell chymase (Cma) could be activated by each other in the heart under inflammatory conditions [25]. Indeed, due to the cardiac inflammation in or RIHD model, Mmp2 was overexpressed in the RT groups irrespective of losartan ...
In response to losartan, the Mmp9 remained significantly overexpressed, and the Mmp2 expression was not significantly different from the control group (Table 5). Table 5. The effects of losartan, mirabegron, and their combination on left ventricular expression of matrix metalloprotease-2 and -9, ...
decreased in aged skin and increased by RA. The levels of NF-κB/AP-1 and MMP1/2/3/9 were increased in aged skin and decreased by RA. The levels of TGF-β, CTGF, and collagen I/III were decreased in aged skin and increased by RA. The expression of laminin and nidogen and ...
The activities as well as expression of MMP-2 and MMP-9 were measured by MMP activity ELISA kits and Western blotting, respectively. Their possible regular pathways, e.g., p38 MAKP, ERK1/2, Akt, and NF-κB, were all analyzed after the treatment of DEHP. 2. Results and Discussion 2.1...